α-烯醇化酶调控肿瘤的作用机制及靶向干预研究进展  

Progress of Research on the Mechanism of Enolase 1 in Regulating Tumors and Targeting Intervention

作　　者：谢飞 戴昕彤 山长亮 XIE Fei;DAI Xintong;SHAN Changliang(Collegeof Pharmacy,Nankai University,Tianjin300350,China)

机构地区：[1]南开大学药学院,天津300350

出　　处：《药学进展》2025年第4期255-266,共12页Progress in Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目(No.82373906)。

摘　　要：烯醇化酶(enolase 1,ENO1)是糖酵解途径中的关键酶,负责催化2-磷酸甘油酸(2-phosphoglycerate,2-PG)向磷酸烯醇式丙酮酸(phosphoenolpyruvate,PEP)的转化。ENO1作为一种多功能蛋白,在细胞表面及细胞质中均有表达,其在糖酵解过程中的作用不仅限于代谢调节,还包括促进肿瘤细胞增殖和抑制细胞凋亡。该酶的表达不受生长抑制因子的调控,从而促进肿瘤细胞的免疫逃逸。ENO1在多种癌症类型中的过表达,使其成为肿瘤治疗的潜在靶点,同时亦是癌症预后和诊断的重要生物标志物。综述了ENO1与癌症关系的最新研究进展,探讨了其作为癌症生物标志物的潜力,并讨论了小分子药物靶向ENO1在肿瘤治疗策略中的潜在应用。Enolase 1(ENO1),a key enzyme in the glycolytic pathway,catalyzes the conversion of 2-phosphoglycerate(2-PG)to phosphoenolpyruvate(PEP).As a multifunctional protein,ENO1 is expressed on the cell surface and in the cytoplasm.Its role in glycolysis extends beyond metabolic regulation to promoting tumor cell proliferation and inhibiting apoptosis.The expression of ENO1 is not regulated by growth inhibitors,thus facilitating immune escape in tumor cells.Overexpression of ENO1 in various cancer types makes it a potential target for tumor therapy,and also an important biomarker for cancer prognosis and diagnosis.This review summarizes the latest research advances in the relationship between ENO1 and cancer,explores its potential as a cancer biomarker,and discusses the potential applications of small-molecule drugs targeting ENO1 in tumor treatment.

关 键 词：α-烯醇化酶 肿瘤 小分子抑制剂 

分 类 号：R979.1[医药卫生—药品] R963[医药卫生—药学]