HPV疫苗接种状态与不同手术方式对早期宫颈癌预后的影响  

The impact of HPV vaccination statuses and various surgical techniques on the prognosis of early-stage cervical cancer

作　　者：韩兰蓝 张晓玉 柴珂 段霞光[2] 孙红梅 HAN Lanlan;ZHANG Xiaoyu;CHAI Ke;DUAN Xiaguang;SUN Hongmei(Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou,Inner Mongolia,014040,China;不详)

机构地区：[1]内蒙古科技大学包头医学院,内蒙古包头014040 [2]内蒙古包钢医院

出　　处：《中国冶金工业医学杂志》2025年第2期125-127,共3页Chinese Medical Journal of Metallurgical industry

基　　金：中国金属学会冶金安全与健康分会健康卫生科研项目(jkws202062);包头市卫生健康科研项目(2024wsjkkj120);内蒙古医科大学联合项目(YKD2024LH011)。

摘　　要：目的 探讨人乳头瘤病毒(HPV)疫苗接种状态与不同手术方式对早期宫颈癌(ECC)预后的影响。方法 选取内蒙古包钢医院收治的88例ECC患者,根据HPV疫苗接种状态和手术方式将其分为A组23例、B组23例、C组21例和D组21例,手术方式包括宫颈环形电切术(LEEP术)、冷刀锥切术(CKC术),比较4组的疗效相关指标。结果 4组的手术时间、出血量比较均差异显著(F=144.390、95.960,均P<0.05);4组并发症比较差异显著(χ^(2)=15.590,P<0.05);术后6个月,4组鳞状细胞癌抗原(SCC-Ag)水平均低于术前且以C组SCC-Ag降低更为显著(F=34.470,P<0.05);术后1年,4组术后复发率和HPV感染率比较均差异显著(χ^(2)=18.411、15.588,均P<0.05),其中C组、D组更低。结论 与CKC术相比,接受LEEP术患者的手术时间短、术中出血量少、并发症发生率低;HPV疫苗联合手术治疗的患者术后SCC-Ag水平、复发与感染风险均显著降低。Objective To explore the impact of human papillomavirus(HPV) vaccination status and different surgical methods on the prognosis of early-stage cervical cancer(ECC).Methods A total of 88 ECC patients treated at Baogang Hospital in Inner Mongolia were selected and divided into four groups based on their HPV vaccination status and surgical methods:Group A(n=23),Group B(n=23),Group C(n=21),and Group D(n=21).Surgical methods included loop electrosurgical excision procedure(LEEP) and cold knife conization(CKC).Efficacy-related indicators were compared among the four groups.Results Significant differences were observed among the four groups in terms of surgical duration and intraoperative blood loss(F=144.390,95.960;both P<0.05).Complication rates also varied significantly among the groups (χ^(2)=15.590,P<0.05).Six months postoperatively,squamous cell carcinoma antigen(SCC-Ag) levels in four groups were lower than preoperative levels,with the most significant reduction observed in Group C(F=34.470,P<0.05).At one year postoperatively,the recurrence and HPV infection rates differed significantly among the four groups (χ^(2)=18.411,15.588;both P<0.05),with Groups C and D showing lower rates.Conclusion Compared to CKC,LEEP offers shorter surgical duration,less intraoperative blood loss,and lower complication rates.Patients receiving combined HPV vaccination and surgical treatment demonstrated significantly reduced postoperative SCC-Ag levels,recurrence rates,and infection risks.

关 键 词：HPV疫苗 ECC LEEP术 CKC术 

分 类 号：R737[医药卫生—肿瘤]