多肽自组装及其作为药物载体的研究进展  

Progress in self-assembly of peptides and its applications as drug carriers

作　　者：陈文静 陈号东 赵东欣[1] CHEN Wen-Jing;CHEN Hao-Dong;ZHAO Dong-Xin(School of Chemistry and Chemical Engineering,Henan University of Technology,Zhengzhou 450001,China)

机构地区：[1]河南工业大学化学化工学院,郑州450001

出　　处：《生命科学》2025年第3期329-336,共8页Chinese Bulletin of Life Sciences

基　　金：河南工业大学科研基金项目(51001089);河南省高等教育教学改革研究与实践项目(2023-SJGLX041Y)。

摘　　要：多肽分子通过多种作用力的协同作用,能在一定的条件下发生自组装,从而形成有序的稳定的三维结构与形态,并表现出特殊的性能。加之多肽具有良好的生物相容性和设计灵活性,多肽自组装体具有较高的研究与应用价值。本文对多肽的自组装机制、影响多肽自组装的因素(氨基酸手性与序列、温度、pH、肽浓度、离子强度、超声波及酶刺激)以及多肽自组装体在药物输运方面的应用进行了简要总结,希望可以为多肽研究工作者提供一些信息支持。Peptide molecules possess the ability to self-assemble under specific conditions,driven by the concerted influence of various intermolecular forces.This process leads to the formation of well-ordered and stable threedimensional architectures and morphologies,which in turn exhibit unique properties.Moreover,peptides are characterized by their excellent biocompatibility and design flexibility,rendering the study of peptide self-assembly both scientifically intriguing and practically significant.This article provides a concise overview of the mechanisms underlying peptide self-assembly,the factors that influence this process(such as amino acid chirality and sequence,temperature,pH,peptide concentration,ion strength,ultrasound,and enzymatic stimuli),and the application of peptide self-assembly in drug delivery,hoping to provide references for researchers engaged in this field.

关 键 词：多肽 三维结构 自组装 药物载体 

分 类 号：Q71[生物学—分子生物学] R915[医药卫生—微生物与生化药学]