中国干眼人群睡眠异常患病率的Meta分析  

Meta-analysis of the incidence of sleep abnormalities in the dry eye population in China

作　　者：柯殷雨 周露宇 罗世春 张富文 Ke Yinyu;Zhou Luyu;Luo Shichun;Zhang Fuwen(Eye School of Chengdu University of TCM,Chengdu,Sichuan,610075;Key Laboratory of Sichuan Province Ophthalmopathy Prevention&Cure and Visual Function Protection with TCM,Chengdu,Sichuan,610075;Retinal Image Technology and Chronic Vascular Disease Prevention&Control and Collaborative Innovation Center,Chengdu,Sichuan,610075;Ineye Hospital of Chengdu University of TCM,Chengdu,Sichuan,610084)

机构地区：[1]成都中医药大学眼科学院,四川成都610075 [2]中医药眼病防治与视功能保护四川省重点实验室,四川成都610075 [3]视网膜图像技术与慢性血管性疾病防治协同创新中心,四川成都610075 [4]成都中医大银海眼科医院,四川成都610084

出　　处：《中医眼耳鼻喉杂志》2025年第2期87-90,100,共5页Journal of Chinese Ophthalmology and Otorhinolaryngology

基　　金：四川省自然科学基金项目资助(编号:2023NSFSC0690)。

摘　　要：目的评估中国干眼患者睡眠异常的患病率及流行特征。方法系统检索中英文数据库(建库至2024年12月),筛选相关研究。两名研究者独立筛选文献、提取数据及评估偏倚风险,采用Stata17.0和RevMan5.3进行Meta分析。结果共纳入19篇中文研究(4348例),总体质量中等偏上。Meta分析显示,中国干眼人群睡眠异常患病率为50.00%[95%CI(0.41,0.58),P<0.00001]。亚组分析表明地区差异显著:华东(30.00%)、华北(50.00%)、西南(62.00%)、西北(52.00%),不同诊断工具(如PSQI量表)、性别、年龄及睡眠时长的患病率差异有统计学意义(P<0.01)。结论中国干眼患者睡眠异常高发且存在地域和评估方法差异,临床需关注其睡眠健康。当前研究受限于仅纳入中文文献,未来需多语言高质量研究验证结果,降低潜在偏倚。Objective To assess the prevalence and epidemiological characteristics of sleep disorders in Chinese patients with dry eye disease(DED)through a meta-analysis.Methods A systematic search was conducted across Chinese and English databases for studies published from inception to December 2024.Two researchers independently screened studies,extracted data,and assessed bias risk.Meta-analysis was performed using Stata 17.O and RevMan 5.3.Results Nineteen Chinese studies involving 4,348 patients were included,with moderate-to-high quality.The pooled prevalence of sleep disorders in Chinese DED patients was 50.00%[95%CI(0.41,0.58),P<0.00001].Subgroup analysis revealed significant regional variations:East China(30.00%[95%CI(0.24,0.36)]),North China(50.00%[95%CI(0.33,0.67)]),Southwest China(62.00%[95%CI(0.43,0.81)]),and Northwest China(52.00%[95%CI(0.25,0.79)]).Significant differences were observed across diagnostic tools(e.g.,PSQI scale),gender,age,and sleep duration(P<O.O1).Conclusion Sleep disorders are highly prevalent in Chinese DED patients,with notable regional and methodological heterogeneity.Clinical attention to sleep health in DED management is crucial.A key limitation is the inclusion of Chinese-only studies;future research should incorporate multi-language evidence to reduce bias and validate findings.

关 键 词：干眼 睡眠异常 患病率 系统评价 META分析 

分 类 号：R77[医药卫生—眼科]