加减地黄饮子治疗肾虚型症状性颅内动脉狭窄性脑卒中的临床效果  

Clinical Effect of Rehmannia Decoction in Treating Cerebral Apoplexy Caused by Symptomatic Intracranial Artery Stenosis Stroke of Kidney Deficiency Type

作　　者：李恒楠 孙晗 LI Heng-Nan;SUN Han(Internal Medicine Department of Yiwu Hospital of Traditional Chinese Medicine,Jinhua 322000,China)

机构地区：[1]义乌市中医医院内一科,浙江金华322000

出　　处：《中国药物经济学》2025年第3期47-50,共4页China Journal of Pharmaceutical Economics

基　　金：义乌市科技局计划项目(21-3-26)。

摘　　要：目的探讨加减地黄饮子治疗肾虚型症状性颅内动脉狭窄(s ICAS)性脑卒中的临床效果。方法选取2022年3月至2023年10月义乌市中医医院收治的肾虚型sICAS性脑卒中患者80例,按随机数字表法分为对照组与观察组,各40例。对照组予以常规治疗,观察组在对照组基础上采用加减地黄饮子治疗。比较两组患者疗效、神经功能、生活能力及不良反应。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);相比对照组,观察组治疗2周、治疗4周、随访12周美国国立卫生研究院卒中量表(NIHSS)评分较低,差异有统计学意义(P<0.05);相比对照组,观察组随访12周Barthel指数评分较高,差异有统计学意义(P<0.05);观察组不良反应与对照组比较,差异无统计学意义(P>0.05)。结论肾虚型sICAS性脑卒中患者采用加减地黄饮子治疗效果较好,可改善神经功能,提升生活能力,且安全性较高。Objective To explore the clinical effect of Rehmannia decoction in treating cerebral apoplexy caused by symptomatic intracranial artery stenosis(sICAS)of kidney deficiency type.Methods A total of 80 patients with sICAS stroke of kidney deficiency type admitted to Yiwu Hospital of Traditional Chinese Medicine from March 2022 to October 2023 were selected and divided into control group and observation group according to random number table method,with 40 cases in each group.The control group was treated with routine treatment,and the observation group was treated with Rehmannia decoction on the basis of control group.The efficacy,neurological function,life ability and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Compared with the control group,the National Institutes of Health Stroke Scale(NIHSS)score of the observation group was lower after 2 weeks of treatment,4 weeks of treatment and 12 weeks of follow-up,and the difference was statistically significant(P<0.05).Compared with the control group,the Barthel index score of the observation group was higher at 12 weeks follow-up,and the difference was statistically significant(P<0.05).There was no significant difference in adverse reactions between observation group and control group(P>0.05).Conclusion The treatment of sICAS stroke patients of kidney deficiency type with Rehmannia decoction is effective,which can improve nerve function and life ability,and has good safety.

关 键 词：症状性颅内动脉狭窄 脑卒中 肾虚型 加减地黄饮子 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R289.5[医药卫生—临床医学]