米曲菌胰酶联合益生菌治疗功能性腹泻的效果及对复发率的影响  

Effect of Aspergillus Oryzae Pancrease combined with Probiotics on Functional Diarrhea and Its Effect on Recurrence Rate

作　　者：孙小艳 SUN Xiao-Yan(Department of Gastroenterology,The First Hospital of Dandong,Dandong 118000,China)

机构地区：[1]丹东市第一医院消化内科,辽宁丹东118000

出　　处：《中国药物经济学》2025年第3期51-54,59,共5页China Journal of Pharmaceutical Economics

摘　　要：目的探讨米曲菌胰酶联合益生菌治疗功能性腹泻的效果及对复发率的影响。方法将2020年1月至2023年1月丹东市第一医院收治的82例功能性腹泻患者随机分为益生菌组与联合组,各41例。益生菌组单纯口服酪酸梭菌活菌片,联合组在对照组基础上增加米曲菌胰酶片。比较两组患者临床疗效,排便次数及相关症状评分,相关血清生化指标[胃泌素-17(G-17)、胃蛋白酶原Ⅱ(PGⅡ)、胃蛋白酶原Ⅰ(PGⅠ)],用药期间不良反应发生情况与随访1年复发情况。结果联合组临床总有效率高于益生菌组(P<0.05);治疗前两组排便次数、大便性状评分、腹胀评分比较无明显差异(P>0.05);治疗后两组排便次数、大便性状评分、腹胀评分均降低(P<0.05),且联合组比益生菌组均更低(P<0.05);治疗前两组血清G-17、PGⅡ、PGⅠ水平比较无明显差异(P>0.05);治疗后两组血清G-17、PGⅡ、PGⅠ水平均升高(P<0.05),且联合组比益生菌组均更高(P<0.05);两组治疗期间均无明显不良反应发生,通过1年随访,均无失访病例,联合组随访期间功能性腹泻复发率为4.88%,益生菌组复发率为31.71%,两组相比差异有统计学意义(P<0.05)。结论米曲菌胰酶联合益生菌治疗功能性腹泻效果显著,且与单纯益生菌治疗相比可减少排便次数,改善大便性状与腹胀情况,提高相关血清生化指标水平,降低远期复发率,且安全性较高。Objective To explore the effect of Aspergillus oryzae pancrease combined with probiotics on functional diarrhea and its effect on recurrence rate.Methods A total of 82 patients with functional diarrhea admitted to the First Hospital of Dandong City from January 2020 to January 2023 were randomly divided into probiotic group and combination group,with 41 cases each.Probiotics group was given live clostridium butyricum tablets alone,and the combined group was added rice aspergillus pancreatic enzyme tablets on the basis of control group.The clinical efficacy,the frequency of defecation and related symptom scores,the relevant serum biochemical indexes of gastrin-17(G-17),pepsinogenⅡ(PG-Ⅱ),pepsinogenⅠ(PG-Ⅰ),the occurrence of adverse reactions during medication and the recurrence of 1-year follow-up were compared between the two groups.Results The total clinical effective rate of the combined group was higher than that of the probiotic group(P<0.05).There were no significant differences in defecation frequency,stool trait score and abdominal distension score between the two groups before treatment(P>0.05).After treatment,the frequency of defecation,stool trait score and abdominal distension score were all decreased(P<0.05),and the combined group was lower than the probiotic group(P<0.05).There were no significant differences in serum G-17,PG-Ⅱand PG-Ⅰlevels between two groups before treatment(P>0.05).After treatment,the serum levels of G-17,PG-Ⅱand PG-Ⅰin 2 groups were increased(P<0.05),and those in combination group were higher than those in probiotic group(P<0.05).No significant adverse reactions occurred in the two groups during treatment,and no cases were lost to follow-up through 1-year follow-up.The recurrence rate of functional diarrhea was 4.88%in the combined group and 31.71%in the probiotic group during follow-up,with statistical significance between the two groups(P<0.05).Conclusion The combination of Monascus trypsin and probiotics has a significant effect on the treatment of functional dia

关 键 词：米曲菌胰酶 益生菌 功能性腹泻 复发率 胃蛋白酶原 胃泌素-17 

分 类 号：R574.4[医药卫生—消化系统] R975[医药卫生—内科学]