二十五味珊瑚丸联合丙戊酸钠治疗癫痫的效果  

Therapeutic Effect of Shiwuwei Coral Pill combined with Sodium Valproate in the Treatment of Epilepsy

作　　者：韩雪 刘海兵 HAN Xue;LIU Hai-Bing(Department of Neurology,Liaoning Shengjian Health Industry Group Fuxin Mining Hospital,Fuxin 123000,China)

机构地区：[1]辽宁省健康产业集团阜新矿总医院神经内科,辽宁阜新123000

出　　处：《中国药物经济学》2025年第3期64-68,共5页China Journal of Pharmaceutical Economics

摘　　要：目的探讨二十五味珊瑚丸联合丙戊酸钠治疗癫痫的效果。方法选取2021年1月至2023年12月辽宁省健康产业集团阜新矿总医院收治的80例癫痫患者,随机分为对照组与观察组,各40例。对照组采用丙戊酸钠,观察组采用二十五味珊瑚丸联合丙戊酸钠。比较两组疗效、认知功能、氧化应激指标和炎症因子水平、不良反应。结果观察组治疗有效率明显高于对照组(P<0.05);治疗前,两组记忆能力、时间感、操作能力、分辨能力、专注力、沟通能力、数字运算和推理能力评分无明显差异(P>0.05);治疗后,两组记忆能力、时间感、操作能力、分辨能力、专注力、沟通能力、数字运算和推理能力评分明显升高(P<0.05),且观察组高于对照组(P<0.05);治疗前,两组血清过氧化氢酶(CAT)、脂质过氧化物(LPO)、晚期蛋白质氧化产物(AOPP)、髓过氧化物酶(MPO)水平无明显差异(P>0.05);治疗后,两组血清CAT、LPO、AOPP、MPO水平降低(P<0.05),且观察组血清CAT、LPO、AOPP、MPO水平低于对照组(P<0.05);治疗前,两组血清白细胞介素-1β(IL-1β)、高迁移率族蛋白(HMGB-1)、白细胞介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)水平无明显差异(P>0.05);治疗后,两组血清IL-1β、HMGB-1、IL-2、TNF-α水平降低(P<0.05),且观察组血清IL-1β、HMGB-1、IL-2、TNF-α水平低于对照组(P<0.05);两组头痛、恶心、胃部不适和过敏性皮疹发生率无明显差异(P>0.05)。结论二十五味珊瑚丸联合丙戊酸钠能有效改善癫痫患者的认知功能,减轻炎症反应及氧化应激,提高疗效。Objective To explore the effect of Shiwuwei Coral Pill combined with Sodium Valproate in the treatment of epilepsy.Methods A total of 80 patients with epilepsy admitted to Fuxin Mine General Hospital of Liaoning Health Industry Group from January 2021 to December 2023 were randomly divided into control group and observation group,with 40 patients in each group.The control group was treated with sodium valproate,and the observation group was treated with 25 flavor coral pills combined with sodium valproate.The effects,cognitive function,levels of oxidative stress and inflammatory factors and adverse reactions were compared between the two groups.Results The effective rate of the observation group was significantly higher than that of the control group(P<0.05).Before treatment,there were no significant differences in the scores of memory ability,time sense,operation ability,resolution ability,concentration ability,communication ability,number arithmetic and reasoning ability between the two groups(P>0.05).After treatment,the scores of memory ability,sense of time,operation ability,resolution ability,concentration ability,communication ability,number arithmetic ability and reasoning ability of two groups were significantly increased(P<0.05),and the observation group was higher than the control group(P<0.05).Before treatment,there were no significant differences in serum catalase(CAT),lipid peroxides(LPO),late protein oxidation products(AOPP)and myeloperoxidase(MPO)levels between two groups(P>0.05).After treatment,the serum levels of CAT,LPO,AOPP and MPO in 2 groups were decreased(P<0.05),and the serum levels of CAT,LPO,AOPP and MPO in observation group were lower than those in control group(P<0.05).Before treatment,there were no significant differences in serum levels of interleukin-1β(IL-1β),high mobility group protein(HMGB-1),interleukin-2(IL-2)and tumor necrosis factor-α(TNF-α)between two groups(P>0.05).After treatment,the serum levels of IL-1β,HMGB-1,IL-2 and TNF-αin 2 groups were decreased(P<0.05),and the

关 键 词：二十五味珊瑚丸 丙戊酸钠 癫痫 认知功能 炎症反应 氧化应激 

分 类 号：R749.1[医药卫生—神经病学与精神病学] R971[医药卫生—临床医学]