依达拉奉右莰醇联合阿替普酶治疗急性脑梗死患者的效果  

Effects of Edaravone and Dexborneol combined with Alteplase in treatment of patients with acute cerebral infarction

作　　者：王秀梅 WANG Xiumei(Department of Pharmacy of Zhoukou First People’s Hospital,Zhoukou 466700 Henan,China)

机构地区：[1]周口市第一人民医院药学部,河南周口466700

出　　处：《中国民康医学》2025年第8期13-16,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察依达拉奉右莰醇联合阿替普酶治疗急性脑梗死(ACI)患者的效果。方法:选取2022年12月至2023年12月该院收治的84例ACI患者进行前瞻性研究,按照随机数字表法将其分为对照组和研究组各42例。对照组给予阿替普酶治疗,研究组在对照组基础上联合依达拉奉右莰醇治疗。比较两组临床疗效,治疗前后神经传导指标[皮质潜伏期(CL)、中枢运动传导时间(CMCT)、中枢传导时间(CCT)]、T细胞亚群指标(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))、炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)]水平,以及不良反应发生率。结果:研究组治疗总有效率为92.86%(39/42),高于对照组的73.81%(31/42),差异有统计学意义(P<0.05);治疗后,两组CL、CMCT、CCT等神经传导指标水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组CD4^(+)、CD4^(+)/CD8^(+)水平均高于治疗前,且研究组高于对照组,两组CD8^(+)水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组TNF-α、IL-1β、IL-6等炎性因子水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率为2.38%(1/42),低于对照组的19.05%(8/42),差异有统计学意义(P<0.05)。结论:依达拉奉右莰醇联合阿替普酶治疗ACI患者可提高治疗总有效率,改善T细胞亚群指标水平,以及降低神经传导指标水平、炎性因子水平和不良反应发生率,效果优于单纯阿替普酶治疗。Objective:To observe effects of Edaravone and Dexborneol combined with Alteplase in treatment of patients with acute cerebral infarction(ACI).Methods:A prospective study was conducted on 84 patients with ACI admitted to the hospital from December 2022 to December 2023.According to the random number table method,they were divided into control group and study group,42 cases in each group.The control group was treated with Alteplase,while the study group was treated with Edaravone and Dexborneol on the basis of that of the control group.The clinical efficacies,the levels of nerve conduction indexes[cortical latency(CL),central motor conduction time(CMCT),central conduction time(CCT)],T cell subsets indexes(CD4^(+),CD8^(+),CD4^(+)/CD8^(+))and inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),interleukin-6(IL-6)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 92.86%(39/42),which was higher than 73.81%(31/42)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of nerve conduction indexes such as CL,CMCT and CCT in the two groups were lower than those before the treatment,those in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CD4^(+)and CD4^(+)/CD8^(+)in the two groups were higher than those before the treatment,and those in the study group were higher than those in the control group;the levels of CD8^(+)in the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of inflammatory factors such as TNF-α,IL-1βand IL-6 in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and th

关 键 词：阿替普酶 依达拉奉右莰醇 急性脑梗死 T细胞亚群 神经传导 炎性因子 不良反应 

分 类 号：R743.33[医药卫生—神经病学与精神病学]