香砂六君子汤联合常规四联疗法治疗幽门螺杆菌阳性十二指肠溃疡患者的效果  

Effects of Xiangsha Liujunzi decoction combined with conventional quadruple therapy on patients with Helicobacter pylori-positive duodenal ulcer

作　　者：蒋春鹤 JIANG Chunhe(Department of Spleen,Stomach,Hepatobiliary of Shangqiu Hospital of Traditional Chinese Medicine,Shangqiu 476600 Henan,China)

机构地区：[1]商丘市中医院脾胃肝胆科,河南商丘476600

出　　处：《中国民康医学》2025年第8期119-122,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察香砂六君子汤联合常规四联疗法治疗幽门螺杆菌(Hp)阳性十二指肠溃疡患者的效果。方法:回顾性分析2021年3月至2023年2月该院收治的85例Hp阳性十二指肠溃疡患者的临床资料,根据治疗方法不同将其分为对照组(n=42)和观察组(n=43)。对照组给予常规四联疗法治疗,观察组在对照组基础上联合香砂六君子汤治疗。比较两组Hp根除率,临床疗效,治疗前后胃肠激素[胃泌素(GAS)、胃蛋白酶原(PG)、生长抑素(SS)]水平、中医证候积分(脘腹胀满、恶心呕吐、食欲不振、口苦口干),以及不良反应发生率。结果:观察组Hp清除率为93.02%(40/43),高于对照组的76.19%(32/42),差异有统计学意义(P<0.05);观察组治疗总有效率为95.35%(41/43),高于对照组的80.95%(34/42),差异有统计学意义(P<0.05);治疗后,两组GAS、SS、PG水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组脘腹胀满、恶心呕吐、食欲不振、口苦口干等中医证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为4.65%(2/43),低于对照组的21.43%(9/42),差异有统计学意义(P<0.05)。结论:香砂六君子汤联合常规四联疗法治疗Hp阳性十二指肠溃疡患者,可提高Hp清除率和临床疗效,调节胃肠激素水平,降低中医证候积分和不良反应发生率,效果优于单纯四联疗法治疗。Objective:To observe effects of Xiangsha Liujunzi decoction combined with conventional quadruple therapy on patients with Helicobacter pylori(Hp)-positive duodenal ulcer.Methods:The clinical data of 85 patients with Hp-positive duodenal ulcer admitted to this hospital from March 2021 to February 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group(n=42)and observation group(n=43).The control group was treated with conventional quadruple therapy,while the observation group was treated with Xiangsha Liujunzi decoction on the basis of that of the control group.The Hp eradication rate,the clinical efficacy,the levels of gastrointestinal hormones[gastrin(GAS),pepsinogen(PG),somatostatin(SS)],the Traditional Chinese Medicine(TCM)syndrome scores(abdominal fullness and distention,nausea and vomiting,loss of appetite,bitter mouth and dry mouth)before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The Hp clearance rate of the observation group was 93.02%(40/43),which was higher than 76.19%(32/42)of the control group,and the difference was statistically significant(P<0.05).The total effective rate of treatment in the observation group was 95.35%(41/43),which was higher than 80.95%(34/42)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of GAS,SS and PG in the two groups were higher than those before the treatment,those in the observation group were higher those in than the control group,and the differences were statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as abdominal fullness and distention,nausea and vomiting,loss of appetite,bitter mouth and dry mouth in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the observation

关 键 词：香砂六君子汤 四联疗法 幽门螺杆菌 十二指肠溃疡 胃肠激素 不良反应 

分 类 号：R573.1[医药卫生—消化系统]