不同步态模式下的肌肉协同与大腿截肢者肌肉代偿机制分析  

Analysis of Muscle Synergies and Compensation Mechanisms in Thigh Amputees under Different Gait Patterns

作　　者：周润 吕阳 张晓旭 陈文明 徐鉴 ZHOU Run;LÜYang;ZHANG Xiaoxu;CHEN Wenming;XU Jian(Academy for Engineering and Technology,Fudan University,Shanghai 200433,China;Engineering Research Center of Intelligent Robotics,Shanghai 200433,China;Engineering Research Center of Intelligent Robotics,Ministry of Education,Shanghai 200433,China)

机构地区：[1]复旦大学工程与应用技术研究院,上海200433 [2]上海智能机器人工程技术研究中心,上海200433 [3]智能机器人教育部工程研究中心,上海200433

出　　处：《医用生物力学》2025年第2期307-315,共9页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(12372065,12372022)。

摘　　要：目的探讨健康人和膝上截肢患肢者健侧下肢与残肢在不同步态时肌肉协同的差异,为假肢的肌电控制提供依据。方法采集7位健康人和3位下肢截肢患者在平地行走、上下坡和上下楼梯时7块肌肉(4块大腿肌肉、3块小腿肌肉)的表面肌电信号,通过级联非负矩阵分解(concatenated non-negative matrix factorization,CNMF)提取肌肉协同权重W和时间激活系数H,利用决定系数R2对比W,基于统计参数映射(statistical parametric mapping,SPM)对比H,并选取激活峰值和激活积分进行层次聚类。结果W对比结果显示,健康组和截肢组健肢存在1组相似的协同模式,而残肢侧的协同变异性更高。H比较表明,所有截肢者在整个步态周期上显示出统计学显著差异。时域特征的聚类表明,截肢被试在上坡时健肢侧肌肉需要更大的激活积分和激活峰值。结论本研究深入探讨了下肢截肢者在不同步态的神经肌肉代偿策略,有助于对其步态康复提供理论指导,并助力于开发肌电信号控制的假肢。Objective To explore the differences in muscle synergies of healthy individuals,intact limbs and residual limbs of above-knee amputees under different gaits,provide references for electromyographic control of the prosthetics.Methods Surface electromyography(sEMG)signals of 7 muscles(4 thigh muscles,3 calf muscles)were collected from 7 healthy individuals and 3 lower-limb amputees during level walking,ascending/descending slopes,and ascending/descending stairs.Muscle synergy weights(W)and temporal activation coefficients(H)were extracted using concatenated non-negative matrix factorization(CNMF).The W matrices were compared using the coefficient of determination R2,and the activation coefficients were analyzed using statistical parametric mapping(SPM).Furthermore,peak activation and activation integral were used for hierarchical clustering analysis.Results The comparison of W matrices indicated a similar set of muscle synergies between the healthy group and the intact limb of amputees,whereas the residual limb showed greater variability in synergies.The analysis of H showed statistically significant differences in muscle activation throughout the gait cycle for all amputees.Clustering of time-domain features revealed that amputees exhibited higher activation integral and peak values in their intact limb during ascending slopes.Conclusions This study provides an in-depth investigation of the neuromuscular compensation strategies in lower-limb amputees under different gaits,offering theoretical insights for gait rehabilitation and assisting in the development of EMGcontrolled prosthetics.

关 键 词：表面肌电 肌肉协同 非负矩阵分解 肌肉代偿 大腿截肢者 假肢 

分 类 号：R318.01[医药卫生—生物医学工程]