四君子汤及其活性成分调节肿瘤免疫微环境的研究进展  

Research progress on the regulation of tumor immune microenvironment by Sijunzi Decoction and its active ingredients

作　　者：夏文婷 樊志敏[1,2] 王璐 XIA Wenting;FAN Zhimin;WANG Lu(Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing 210022,China;Jiangsu Clinical Innovation Center for Anorectal Diseases of Traditional Chinese Medicine,Nanjing 210022,China)

机构地区：[1]南京中医药大学附属南京中医院,南京210022 [2]江苏省中医肛肠疾病临床创新中心,南京210022

出　　处：《天津中医药》2025年第5期669-674,共6页Tianjin Journal of Traditional Chinese Medicine

基　　金：江苏省重点研发计划(社会发展)项目(BE2021611)。

摘　　要：恶性肿瘤作为临床上难以治愈的慢性消耗类疾病,传统治疗多以手术、放疗、化疗等为主。近年来,免疫调节肿瘤微环境的研究愈加丰富,已逐渐成为肿瘤治疗的新方向。人体肿瘤免疫微环境中成分复杂,有些甚至能干扰免疫系统的监视与作用,中医药学素以整体观念为重,将肿瘤看作全身性疾病,不拘泥于肿瘤所在人体局部范围内的诊治,通过对免疫微环境的多方面调节,能够有效缓解免疫抑制状态。文章聚焦于肿瘤免疫微环境中的免疫细胞,总结了近五年来四君子汤及主要活性成分对肿瘤免疫微环境的调节作用,以期为其在抗肿瘤的临床应用中提供多方面的理论依据。Malignant tumors,as clinically incurable chronic wasting diseases,are mostly treated with surgery,radiotherapy and chemotherapy in traditional treatment.In recent years,the research on immune regulation of tumor microenvironment has become richer and richer,and has gradually become a new direction of tumor treatment.The immune microenvironment of human tumors has complex components,some of which can even interfere with the surveillance and action of the immune system.Chinese medicine has a holistic view,which regards tumors as systemic diseases,and is not confined to the diagnosis and treatment of tumors within the local scope of the human body,and can effectively alleviate the state of immune suppression through the multifaceted regulation of immune microenvironment.Focusing on the immune cells in the tumor immune microenvironment,the article summarizes the regulatory effects of Sijunzi Decoction and its main active ingredients on the tumor immune microenvironment in the past five years,with a view to providing a theoretical basis for its clinical application in antitumor therapy.

关 键 词：四君子汤 恶性肿瘤 微环境 免疫细胞 

分 类 号：R730.3[医药卫生—肿瘤]