弥漫大B细胞淋巴瘤患者化疗前后PET代谢脑网络的Hub节点和模块化的差异  

Differences in Hub nodes and modularity of PET metabolic brain network in diffuse large B-cell lymphoma patients pre-and post-chemotherapy

作　　者：杨帆[1] 肖静可 彭岱云 付静瑜 柳江燕[1] YANG Fan;XIAO Jingke;PENG Daiyun;FU Jingyu;LIU Jiangyan(Department of Nuclear Medicine,The Second Hospital of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院核医学科,甘肃兰州730030

出　　处：《分子影像学杂志》2025年第4期397-404,共8页Journal of Molecular Imaging

基　　金：甘肃省科技厅联合基金项目(24JRRA922);兰州大学第二医院萃英科技创新计划应用基础研究(CY2023-MS-B10)。

摘　　要：目的基于18F-FDG PET成像构建弥漫大B细胞淋巴瘤(DLBCL)患者化疗前后代谢脑网络Hub节点和模块化的差异,探讨疾病本身和R-CHOP化疗方案对大脑功能的影响。方法回顾性收集2021年6月~2024年7月在兰州大学第二医院核医学科接受化疗前后全身18F-FDG PET检查的51例DLBCL患者和年龄、性别匹配的30例健康对照。采用Pearson相关系数计算脑区间的相关性构建代谢脑网络。行1000次置换检验比较DLBCL患者与健康对照全局属性、Hub节点和模块化的差异。结果DLBCL患者脑网络Hub节点的数量和分布与健康对照组的差异有统计学意义(P<0.05),但仍保持了小世界网络的特性(Sigma>1.1)。在模块化方面,基线时DLBCL患者脑网络的部分节点模块归属发生变化,化疗后脑网络的模块结构则经历了明显重组,但模块度Q值的差异无统计学意义(P>0.05)。结论疾病本身和R-CHOP化疗药物共同导致DLBCL患者代谢脑网络Hub节点和模块化的改变,从而影响大脑功能。Objective To construct metabolic brain networks in patients with diffuse large B-cell lymphoma(DLBCL)before and after chemotherapy using 18F-FDG PET imaging,and investigate the effect of the disease and R-CHOP chemotherapy regimen on brain function by analyzing differences in hub nodes and modularity.Methods A total of 51 DLBCL patients who underwent whole-body 18F-FDG PET scans before and after chemotherapy at the Nuclear Medicine Department of the Second Hospital of Lanzhou University from June 2021 to July 2024 were included retrospectively,along with 30 age-and sex-matched healthy controls.Inter-regional brain correlations were calculated using the Pearson correlation coefficient to construct the metabolic brain network.Graph theory-based analysis and 1000 permutation tests were subsequently employed to compare the differences in global metrics,Hub nodes,and modularity between DLBCL patients and healthy controls.Results Within the sparsity range of 0.1 to 0.5,DLBCL patients exhibited significant differences in the number and distribution of Hub nodes compared to healthy controls(P<0.05),while maintaining small-world properties(Sigma>1.1).Regarding modularity,alterations in node module assignments were noted in the metabolic brain networks of DLBCL patients at baseline,and the modular structure underwent significant reorganization following chemotherapy.Nevertheless,no significant difference in modularity(Q value)was found when compared to the control group(P>0.05).Conclusion The disease,coupled with R-CHOP chemotherapy regimen,disrupts Hub nodes and modularity of metabolic brain network in DLBCL patients,affecting brain function.

关 键 词：弥漫大B细胞淋巴瘤 正电子发射断层 代谢脑网络 模块化 

分 类 号：R733.1[医药卫生—肿瘤]