^(18)F-FDG PET/CT对CA125水平升高的卵巢癌术后腹膜转移患者的诊断价值  

Diagnostic value of ^(18)F-FDG PET/CT based on elevated CA125 levels for peritoneal metastasis after ovarian cancer surgery

作　　者：苗春燕 刘大湃 高富 俞承成 曼菲达·买买提 蒲武涛 夏露花 MIAO Chunyan;LIU Dapai;GAO Fu;YU Chengcheng;MANFEIDA·Maimaiti;PU Wutao;XIA Luhua(Third Clinical Medical College of Xinjiang Medical University,Urumqi 830011,China;Department of Nuclear Medicine,Cancer Hospital Affiliated to Xinjiang Medical University,Urumqi 830011,China)

机构地区：[1]新疆医科大学第三临床医学院,新疆乌鲁木齐830011 [2]新疆医科大学附属肿瘤医院核医学科,新疆乌鲁木齐830011

出　　处：《分子影像学杂志》2025年第4期446-452,共7页Journal of Molecular Imaging

基　　金：新疆医科大学大学生创新训练项目(S202310760058);教育部产学合作协同育人项目(230805236315631)。

摘　　要：目的对比^(18)F-FDG PET/CT与常规影像学方法对糖类抗原125(CA125)水平升高的卵巢癌术后腹膜转移患者中的诊断价值。方法回顾性分析2022年1月~2023年12月于新疆医科大学附属医院病理确诊为卵巢癌的87例患者,分析术后CA125>35 U/mL异常升高患者经^(18)F-FDG PET/CT检查、经腹超声检查(TAUS)、经阴道超声检查(TVUS)、增强CT(CECT)检查或MRI检查诊断卵巢癌术后腹膜转移的敏感度、特异度、准确度、阳性预测值、阴性预测值等参数,比较4种检查方法诊断卵巢癌术后腹膜转移的诊断性能。结果^(18)F-FDG PET/CT、TAUS、TVUS、CECT检查或MRI检查诊断卵巢癌患者术后发生腹膜转移敏感度分别为96.67%、37.70%、56.67%、79.37%,特异度分别为85.19%、88.46%、92.59%、54.17%,准确度为93.10%、52.87%、67.82%、72.41%,阳性预测值分别为93.54%、88.46%、94.44%、81.97%,阴性预测值分别为92.00%、37.70%、49.02%、50.00%。结论^(18)F-FDG PET/CT对诊断卵巢癌术后CA125升高的患者腹膜转移或复发的准确率较高,能够及早发现腹膜转移病灶。Objective To compare the diagnostic value of^(18)F-FDG PET/CT versus conventional imaging methods in patients with postoperative peritoneal metastasis of ovarian cancer based on elevated CA125 levels.Methods This study retrospectively analyzed 87 postoperative patients diagnosed with ovarian cancer at the Affiliated Hospital of Xinjiang Medical University from January 2022 to December 2023.The diagnostic performance of four imaging modalities were investigated:^(18)F FDG PET/CT,transabdominal ultrasound(TAUS),transvaginal ultrasound(TVUS),contrast-enhanced computed tomography(CECT)or MRI,in detecting peritoneal metastasis in patients with elevated postoperative CA125 levels exceeding 35 U/mL.The parameters compared include sensitivity,specificity,accuracy,positive predictive value,and negative predictive value for each diagnostic method in the context of postoperative peritoneal metastasis in ovarian cancer patients.Results The sensitivities of^(18)F-FDG PET/CT,TAUS,TVUS,CECT or MRI for diagnosing postoperative peritoneal metastasis in ovarian cancer patients were 96.67%,37.70%,56.67%,79.37%,respectively;specificities were 85.19%,88.46%,92.59%,54.17%,respectively;accuracies were 93.10%,52.87%,67.82%,72.41%,respectively;positive predictive values were 93.54%,88.46%,94.44%,81.97%,respectively;negative predictive values were 92.00%,37.70%,49.02%,50.00%,respectively.Conclusion The accuracy of^(18)F-FDG PET/CT in diagnosing peritoneal metastasis or recurrence in patients with elevated CA125 levels following ovarian cancer surgery is high,enabling the early detection of peritoneal metastatic lesions.

关 键 词：^(18)F-FDG PET/CT 常规影像方法 CA125 卵巢癌 腹膜转移 

分 类 号：R737.31[医药卫生—肿瘤]