肺部“炎-癌”转化动物模型研究进展  

Research progress in animal models of lung “inflammation-cancer” transformation

作　　者：陈亚娟 陈兰英[1,2,3] 段文彬 黄玉清 靳旭辉 CHEN Yajuan;CHEN Lanying;DUAN Wenbin;HUANG Yqing;JIN Xuhui(Jiangxi University of Chinese Medicine,Nanchang 330004,China;National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine,Nanchang 330006;Jiangxi Provincial Key Laboratory of Effective Material Basis of TCM(2024SSY07102),Jiangxi University of Chinese Medicine,Nanchang 330004)

机构地区：[1]江西中医药大学,南昌330004 [2]中药固体制剂制造技术国家工程研究中心,南昌昌330006 [3]江西中医药大学中药药效物质基础江西省重点实验室(2024SSY07102),南昌330004

出　　处：《中国比较医学杂志》2025年第3期109-136,共28页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(82060732);江西省药品监督管理局科研项目(2023JS27)。

摘　　要：肺癌是一种严重的肺部肿瘤疾病,其慢性炎症状态的加剧是肺癌形成的先兆。为了更深入地了解肺癌发病机制并开发预防治疗策略,实验研究中相关动物模型被广泛应用,特别是诱导肺癌动物模型被视为了解肺部慢性炎症向肺癌转变阶段的重要切入点,及早干预治疗对于防治肺癌具有重要意义。基于此,本文检索了近年相关文献,从肺癌多种诱发因素包括许多致癌物(4-甲基亚硝胺基-1-3-吡啶基-1-丁酮(nicotine-derived nitrosamine ketone, NNK)、苯并芘(benzopyrene, B[a]P)、二乙基亚硝胺(diethylnirtosamine, DEN)、大气细颗粒物(PM_(2.5))、煤烟、重金属离子、辐射、生物感染等)等方面,综述其所诱发的肺部“炎-癌”转化动物模型,讨论相关致癌物在诱发肺癌中的作用机制,剖析动物模型存在的优点和局限性,展望未来发展方向,旨在对其进行总结概述为今后相关模型建立提供宝贵的参考。Lung cancer is a serious pulmonary tumor, with exacerbation of chronic lung inflammation being a precursor to the development of lung cancer. Relevant animal models are widely used in experimental research, to gain a deeper understanding of the pathogenesis of lung cancer and to develop preventive treatment strategies. Induced lung cancer animal models are of particular importance for understanding the transition from chronic lung inflammation to lung cancer. Early intervention is crucial for the prevention and treatment of lung cancer. Here we review the recent literature regarding the inducing factors for lung cancer, including carcinogens(e.g. nicotine-derived nitrosamine ketone, benzopyrene, diethylnirtosamine atmospheric fine particulate matter(PM_(2.5)), coal smoke, heavy metal ions, radiation, and biological infections). We also summarize animal models of lung inflammation and cancer transformation induced by these factors, discuss the mechanisms by which relevant carcinogens induce lung cancer, analyze the advantages and limitations of the animal models, and consider future development directions. This review aims is to provide a valuable reference for the future establishment of relevant models.

关 键 词：“炎-癌”转化 肺癌 动物模型 诱发机制 优点 局限性 

分 类 号：R-33[医药卫生]