多囊卵巢综合征与卵泡扩张的关系及调控机制研究进展  

Research progress in relationship between polycystic ovary syndrome and ovarian follicle expansion and its regulatory mechanism

作　　者：张轶博 杨历 冯时光 孙洁[4] 郝肖琼 ZHANG Yibo;YANG Li;FENG Shiguang;SUN Jie;HAO Xiaoqiong(Department of Physiology,Baotou Medical College,Baotou 014040,China;Bayannur Clinical Medical College,Baotou Medical College,Baotou 014040;School of Medical Technology and Anesthesiology,Baotou Medical College,Baotou 014040;Department of Pathophysiology,Baotou Medical College,Baotou 014040)

机构地区：[1]包头医学院生理学教研室,内蒙古包头014040 [2]包头医学院巴彦淖尔临床医学院,内蒙古包头014040 [3]包头医学院医学技术与麻醉学院,内蒙古包头014040 [4]包头医学院病理生理学教研室,内蒙古包头014040

出　　处：《中国比较医学杂志》2025年第3期137-146,共10页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(32360181);内蒙古自治区自然科学基金(2022LHMS03012);内蒙古自治区卫生健康科技计划项目(202201376);包头医学院2024年大学生创新创业训练计划项目(S202410130009)。

摘　　要：卵泡扩张是卵泡生长发育为优势卵泡的重要环节,受多种分子及信号调控,主要包括卵泡腔形成、卵泡液积累及颗粒细胞增殖。多囊卵巢综合征(polycystic ovary syndrome, PCOS)是女性最常见的生殖内分泌疾病,患者主要表现为由卵泡扩张不足引起的窦前卵泡增多及卵巢多囊样变。本文综述了近年来有关卵泡扩张生理过程、相关调控因子及机制的新进展,并阐述了PCOS患者卵泡扩张受限的可能因素,以期为卵泡扩张异常导致的卵泡发育不良、排卵障碍等疾病提供理论依据。Ovarian follicle expansion is an important part of their growth and development into dominant follicles, and is regulated by a variety of molecules and signals, including follicular cavity formation, follicular fluid accumulation, and granulosa cell proliferation. Polycystic ovary syndrome(PCOS) is the most common reproductive endocrine disease in women, and patients mainly present with increased preantral follicles and polycystic ovarian lesions caused by inadequate ovarian follicle expansion. This review summarizes recent research developments concerning the physiological process of ovarian follicle expansion and the related regulatory factors and mechanisms. We also consider the possible factors restricting ovarian follicle expansion in patients with PCOS, to provide a theoretical basis for follicular dysplasia, ovulation disorders and other diseases caused by abnormal ovarian follicle expansion.

关 键 词：卵泡扩张 卵泡腔形成 卵泡液积累 颗粒细胞增殖 多囊卵巢综合征 

分 类 号：R-33[医药卫生]