巴戟天寡糖胶囊联合盐酸度洛西汀对抑郁症患者事件相关电位及血清神经递质水平的影响  

Effects of Morinda oligosaccharide capsules combined with duloxetine hydrochloride on the event-related potential and serum neurotransmitter levels in patients with depression

作　　者：王金祥[1] 邵咏[2] 李惠琳 刘蒙[1] WANG Jinxiang;SHAO Yong;LI Huilin;LIU Meng(Department of Clinical Psychology,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,Henan Province,China;Department of Clinical Laboratory,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,Henan Province,China)

机构地区：[1]新乡医学院第二附属医院临床心理科,河南新乡453002 [2]新乡医学院第二附属医院检验科,河南新乡453002

出　　处：《新乡医学院学报》2025年第5期364-368,共5页Journal of Xinxiang Medical University

基　　金：河南省医学科技攻关联合共建项目(编号:LHGJ20230530);新乡医学院第二附属医院精神神经学科开放课题(编号:XYEFYJSSJ-2023-06)。

摘　　要：目的探讨巴戟天寡糖胶囊联合盐酸度洛西汀对抑郁症患者事件相关电位及血清神经递质水平的影响。方法选择2022年7月至2024年8月新乡医学院第二附属医院收治的105例抑郁症患者为研究对象。根据治疗方法将患者分为对照组(n=51)和观察组(n=54),对照组患者给予盐酸度洛西汀治疗,观察组给予巴戟天寡糖胶囊联合盐酸度洛西汀治疗,2组患者均治疗8周。比较2组患者的临床疗效;治疗前、治疗8周后分别采用汉密尔顿抑郁量表-17项(HAMD-17)、蒙特利尔认知评估量表(MoCA)、健康调查简表(SF-36)评估2组患者的抑郁程度、认知功能及生存质量;治疗前、治疗8周时,采用诱发电位仪检测2组患者的事件相关电位P300潜伏期及波幅,高效液相色谱法检测血清5-羟色胺(5-HT)、去甲肾上腺素(NE)水平,酶联免疫吸附法检测血清脑源性神经营养因子(BDNF)、神经元特异性烯醇化酶(NSE)水平。结果观察组患者治疗总有效率显著高于对照组(χ^(2)=5.820,P<0.05)。治疗前2组患者HAMD-17、MoCA、SF-36评分比较差异无统计学意义(P>0.05);与治疗前比较,治疗8周后2组患者的HAMD-17评分显著下降,MoCA、SF-36评分显著上升(P<0.05);治疗8周后,观察组患者的HAMD-17评分显著低于对照组,MoCA、SF-36评分显著高于对照组(P<0.05)。治疗前2组患者事件相关电位P300潜伏期、波幅比较差异无统计学意义(P>0.05);与治疗前比较,治疗8周后2组患者事件相关电位P300潜伏期均显著降低(P<0.05),P300波幅均显著升高(P<0.05);治疗8周后,观察组患者的P300潜伏期显著低于对照组,P300波幅显著高于对照组(P<0.05)。治疗前2组患者血清5-HT、NE、BDNF、NSE水平比较差异无统计学意义(P>0.05);与治疗前比较,治疗8周后2组患者血清5-HT、NE、BDNF水平均显著升高,NSE水平均显著降低(P<0.05);治疗8周后,观察组患者血清5-HT、NE、BDNF水平显著高于对照组,NSE水平显著低于对照�Objective To investigate the effects of Morinda oligosaccharide capsules combined with duloxetine hydrochloride on the event-related potential and serum neurotransmitter levels in patients with depression.Methods One hundred and five patients admitted to the Second Affiliated Hospital of Xinxiang Medical University from July 2022 to August 2024 were selected and divided into a control group(n=51)and an observation group(n=54)according to the treatment methods.The patients in the control group were treated with duloxetine hydrochloride,and those in the observation group were treated with Morinda oligosaccharide capsules and duloxetine hydrochloride at the same time.All patients were treated for 8 weeks,and then the clinical efficacy was compared between the two groups.The Hamilton depression scale-17(HAMD-17),Montreal cognitive assessment scale(MoCA),and summary form of health survey(SF-36)were used to evaluate the depression level,cognitive function,and quality of life of patients in the two groups before treatment and after 8 weeks of treatment.The latency and amplitude of the event-related potential P300 of patients in the two groups were measured using an evoked potential meter.High performance liquid chromatography was used to detect the levels of 5-hydroxytryptamine(5-HT)and noradrenaline(NE).Enzyme-linked immunosorbent assay was used to examine the levels of brain-derived neurotrophic factors(BDNF)and neuron-specific enolase(NSE).Results The total effective rate of patients in the observation group was significantly higher than that in the control group(χ^(2)=5.820,P<0.05).There was no statistically significant difference in HAMD-17,MoCA,and SF-36 scores between the two groups of patients before treatment(P>0.05).The HAMD-17 scores of patients significantly decreased while MoCA and SF-36 scores significantly increased in both groups after 8 weeks of treatment,compared with those before treatment(P<0.05).After 8 weeks of treatment,the HAMD-17 score was significantly lower while MoCA and SF-36 scores were si

关 键 词：抑郁症 巴戟天寡糖胶囊 度洛西汀 相关电位 神经递质 

分 类 号：R749.4[医药卫生—神经病学与精神病学]