血管性痴呆与相关信号通路的关系及中医药调控的研究进展  

Relationship between vascular dementia and related signaling pathways and the research progress of regulation by traditional Chinese medicine

作　　者：段成思 史兰云 赵梅娜 张盟苑 王振[1] 刘志勇[2] DUAN Chengsi;SHI Lanyun;ZHAO Meina;ZHANG Mengyuan;WANG Zhen;LIU Zhiyong(The Second Clinical Medical College,Henan University of Chinese Medicine,Henan Province,Zhengzhou450000,China;Ward Two,Encephalopathy District,Henan Province Hospital of Traditional Chinese Medicine,Henan Province,Zhengzhou450000,China)

机构地区：[1]河南中医药大学第二临床医学院,河南郑州450000 [2]河南省中医院脑病二区,河南郑州450000

出　　处：《中国医药导报》2025年第10期64-68,共5页China Medical Herald

基　　金：河南省中医药科学研究专项课题(20-21ZY1024)。

摘　　要：血管性痴呆(VD)作为一种常见的痴呆类型,显著降低患者的生活质量并加重社会经济负担。近年来,随着对VD发病机制的深入研究,已发现PI3K/Akt、NF-κB、Notch、MAPK等多种信号通路参与其病理过程。中医药在防治VD方面积累了丰富经验,众多研究表明中医药能够通过多靶点、多环节调控相关信号通路,发挥神经保护、抗凋亡、抗炎、抗氧化应激等作用。本文总结近年来VD与相关信号通路的关系及中医药调控VD相关通路及对应机制,旨在为今后开展VD临床与实验研究提供参考。Vascular dementia(VD),as a common type of dementia,significantly reduces patients’quality of life and increases socioeconomic burden.In recent years,with the in-depth study of the pathogenesis of VD,it has been found that a variety of signaling pathways,such as PI3K/Akt,NF-κB,Notch,and MAPK are involved in its pathological process.Traditional Chinese medicine has accumulated rich experience in the prevention and treatment of VD,and numerous studies have shown that traditional Chinese medicine can regulate the related signaling pathways through multi-targets and multi-links to exert neuroprotective,anti-apoptotic,anti-inflammatory,and anti-oxidative stress effects.This article summarizes the relationship between VD and related signaling pathways and the mechanisms of traditional Chinese medicine in regulating VD-related pathways and their counterparts in recent years,with the aim of providing references for future clinical and experimental studies on VD.

关 键 词：血管性痴呆 信号通路 中医药 研究进展 

分 类 号：R749[医药卫生—神经病学与精神病学]