间断性低温治疗对乳腺癌患者白蛋白紫杉醇化疗诱导的外周神经毒性的疗效分析  

Efficacy of intermittent hypothermia therapy on albumin-paclitaxel chemotherapy-induced peripheral neuropathy in breast cancer patients

作　　者：葛超杰 杨波 谌婧超 GE Chaojie;YANG Bo;CHEN Jingchao(Department of Oncology,Jianyang First Hospital of Nanping,Nanping 354200,Fujian,China)

机构地区：[1]南平市建阳第一医院肿瘤科,福建南平3542000

出　　处：《癌症进展》2025年第9期1012-1015,1025,共5页Oncology Progress

摘　　要：目的探讨间断性低温治疗对乳腺癌患者白蛋白紫杉醇化疗诱导的外周神经毒性(CIPN)的疗效。方法将92例乳腺癌患者,按照治疗方式的不同分为对照组60例和观察组32例,对照组实施常规干预,观察组在对照组的基础上实施间歇性低温治疗。比较两组患者神经传导速率、神经毒性[化疗诱导的外周神经毒性问卷(CIPN20)]、生活质量[卡氏功能状态(KPS)评分]、手足综合征(HFS)严重程度、麻木消失时间和不良反应发生情况。结果治疗后,两组患者正中神经传导速率、腓总神经传导速率均增快,且观察组患者正中神经传导速率、腓总神经传导速率均快于对照组,差异均有统计学意义(P﹤0.05)。治疗后,两组患者CIPN20评分均升高,但观察组患者CIPN20评分低于对照组,差异均有统计学意义(P﹤0.05)。治疗后,观察组患者KPS评分高于对照组,HFS发生情况低于对照组,差异均有统计学意义(P﹤0.05)。观察组患者麻木消失时间短于对照组,差异有统计学意义(P﹤0.05)。两组患者恶心、呕吐、腹泻、丙氨酸转氨酶(ALT)升高、天冬氨酸转氨酶(AST)升高发生率比较,差异均无统计学意义(P﹥0.05)。结论间断性低温治疗能够显著改善乳腺癌患者接受白蛋白紫杉醇化疗所致的CIPN,提高神经传导速率,减轻HFS等不良反应,从而提高患者的生活质量。Objective To investigate the efficacy of intermittent hypothermia therapy on albumin-paclitaxel chemotherapy-induced peripheral neuropathy(CIPN)in breast cancer patients.Method A total of 92 breast cancer patients were divided into the control group(n=60)and the observation group(n=32)according to the different treatment methods.The control group was given routine intervention,and the observation group was given intermittent hypothermia therapy on the basis of the control group.Nerve conduction velocity,neurotoxicity[questionnaire for chemotherapy-induced peripheral neuropathy 20-item(CIPN20)scale],quality of life[Karnofsky performance status(KPS)score],severity of hand-foot syndrome(HFS),disappearance time of numbness and adverse reactions were compared between the two groups.Result After treatment,the median nerve conduction velocity and common peroneal nerve conduction velocity of the two groups were increased,and the median nerve conduction velocity and common peroneal nerve conduction velocity of the observation group were faster than those of the control group,the differences were statistically significant(P<0.05).After treatment,the CIPN20 score of the two groups were increased,but the CIPN20 score of the observation group was lower than that of the control group,and the differences were statistically significant(P<0.05).After treatment,the KPS score of the observation group was higher than that of the control group,and the incidence of HFS was lower than that of the control group,and the differences were statistically significant(P<0.05).The disappearance time of numbness in the observation group was significantly shorter than that in the control group,and the difference was statistically significant(P<0.05).There were no significant differences in the incidence of nausea,vomiting,diarrhea,alanine aminotransferase(ALT)elevation and aspartate aminotransferase(AST)elevation between the two groups(P>0.05).Conclusion Intermittent hypothermia therapy can significantly improve CIPN induced by albumin-paclitaxel

关 键 词：间断性低温治疗 乳腺癌 白蛋白紫杉醇 外周神经毒性 疗效 

分 类 号：R737.9[医药卫生—肿瘤]