中缝背核与神经精神疾病关系的研究进展  

Research progress on relationship between dorsal raphe nucleus and neuropsychiatric diseases

作　　者：傅波利 洪浩[1] FU Boli;HONG Hao(School of Pharmacy,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学药学院,江苏南京211198

出　　处：《药学研究》2025年第4期364-370,共7页Journal of Pharmaceutical Research

基　　金：国家自然科学基金面上项目(No.82173805);科技创新2030“脑科学与类脑研究”重大专项(No.2021ZD0203400)。

摘　　要：中缝背核(dorsal raphe nucleus, DRN)位于中脑导水管腹侧,细胞类型众多,涉及神经环路复杂,功能广泛。近年来研究发现DRN可能参与调控睡眠-觉醒、焦虑、抑郁、成瘾等神经精神活动过程。本文对DRN相关神经环路在不同神经精神疾病中的作用及其分子机制进行综述,以期为后续治疗提供新思路。The dorsal raphe nucleus(DRN)is located ventral to the aqueduct of the midbrain,with numerous cell types,complex neural circuits,and a wide range of functions.In recent years,studies have found that DRN may be involved in the regulation of neuropsychiatric processes such as sleep-wakefulness,anxiety,depression,and addiction.This article reviewed the role and molecular mechanism of DRN-related neural circuits in different neuropsychiatric diseases,in order to provide new ideas for subsequent treatment.

关 键 词：中缝背核 神经精神疾病 神经环路 分子机制 

分 类 号：R741.02[医药卫生—神经病学与精神病学]