血小板抗体、交叉配型与骨髓瘤输注无效相关性研究  

Study on the Correlation between Platelet Antibodies Cross Matching and Ineffectiveness of Myeloma Infusion

作　　者：苏情 傅丽霞 巢玲 Su Qing;Fu Lixia;Chao Ling(Yichun People's Hospital,Yichun,Jiangxi,336000;Xinyu People's Hospital,Xinyu Jiangxi 338000,China)

机构地区：[1]宜春市人民医院,江西宜春336000 [2]新余市人民医院,江西新余338000

出　　处：《哈尔滨医药》2025年第2期37-39,共3页Harbin Medical Journal

摘　　要：目的探讨分析血小板抗体、交叉配型结果与多发性骨髓瘤患者血小板输注无效的相关性。方法回顾性分析进行血小板输注的124例多发性骨髓瘤患者,根据患者通过血小板输注后是否有效,分为有效组与无效组,其中有效组有100例,无效组24例。比较两组患者的临床资料、血小板抗体及交叉配型结果等,分析血小板抗体、交叉配型结果与多发性骨髓瘤患者血小板输注无效的相关性及血小板输注无效的影响因素。结果分析结果显示,脾肿大(β=3.524,OR=3.933,95%Cl=7.047~13.397)、发热(β=1.630,OR=5.102,95%Cl=1.389~18.744)、血小板抗体阳性(β=2.114,OR=8.280,95%Cl=2.056~23.340)及交叉配型阳性(β=1.548,OR=4.701,95%Cl=1.104~20.016)均是患者血小板输注无效的影响因素。结论血小板抗体阳性、交叉配型阳性、发热、脾肿大均是多发性骨髓瘤患者血小板输注无效的独立影响因素,临床上应对伴有上述影响因素的多发性骨髓瘤患者给予重视。Objective To explore the correlation between platelet antibodies,cross matching results,and ineffective platelet transfusion in patients with multiple myeloma.Method A retrospective analysis was conducted on 124 patients with multiple myeloma.The patients were divided into an effective group and an ineffective group based on whether platelet transfusion was effective.Among them,there were 100 cases in the effective group and 24 cases in the ineffective group.Compare the clinical data,platelet antibodies,and cross matching results of two groups of patients,and analyze the correlation between platelet antibodies,cross matching results,and ineffective platelet transfusion in patients with multiple myeloma,as well as the influencing factors of ineffective platelet transfusion.Result Factor analysis showed that splenomegaly(β=3.524,...),OR=3.933,95%(Cl=7.047-13.397)、Heat generation(β=1.630,OR=5.102,95%Cl=1.389-18.744)、Platelet antibody positivity(β=2.114,OR=8.280,95%Cl=2.056-23.340)and cross matching positivity(β=1.548,OR=4.701,95%Cl=1.104-20.016)are both influencing factors for ineffective platelet transfusion in patients.Conclusion Positive platelet antibodies,cross matching,fever,and splenomegaly are independent influencing factors for ineffective platelet transfusion in patients with multiple myeloma.Clinical attention should be paid to patients with multiple myeloma who are accompanied by these influencing factors.

关 键 词：血小板抗体 交叉配型 多发性骨髓瘤 血小板输注 

分 类 号：R733.3[医药卫生—肿瘤]