Ⅱ型固有淋巴细胞及其上游分子在过敏性结膜炎发病机制中作用的研究进展  

Research progress in the role of typeⅡinnate lymphoid cells and their upstream molecules in the pathogenesis of allergic conjunctivitis

作　　者：刘齐 郑晓汾[2] Qi Liu;Xiaofen Zheng(Master's degree 2022,the First Clinical Medical College of Shanxi Medical University,Taiyuan 030331,China;Department of Keratology,Shanxi Eye Hospital,Taiyuan 030002,China)

机构地区：[1]山西医科大学第一临床医学院,太原030331 [2]山西医科大学山西省眼科医院角膜病科,太原030002

出　　处：《中华眼科医学杂志(电子版)》2024年第6期368-374,共7页Chinese Journal of Ophthalmologic Medicine(Electronic Edition)

基　　金：山西省医学重点科研项目(2022XCM15)。

摘　　要：过敏性结膜炎(AC)是一种人眼表常见的过敏性疾病,其发病原因复杂,目前公认是由免疫球蛋白E(IgE)或T淋巴细胞介导的一种免疫反应。有研究结果表明,过敏性炎症的主要致病机制之一是辅助型T细胞(Th)2主导的超敏反应,但对其他过敏上游渠道的了解却知之甚少。近年来,有学者发现上皮细胞能通过产生白细胞介素(IL)-33和胸腺基质淋巴细胞生成素(TSLP)等促过敏细胞因子激活Ⅱ型固有淋巴细胞(ILC2),从而调节Th2反应。此外,在木瓜蛋白酶浸泡角膜接触镜所诱导的小鼠结膜炎模型中可见有关眼表先天免疫驱动的2型免疫应答依赖于IL-33、TSLP及嗜碱性粒细胞生成,并可能参与ILC2。基于ILC2、白细胞介素-33及TSLP等上皮促过敏细胞因子在AC发病过程中的作用机制尚未完全阐明。因此,本文中笔者就ILC2及其上游分子在过敏性结膜炎发病机制中的研究现状进行综述。Allergic conjunctivitis(AC)is a common allergic disease of the human ocular surface whose pathogenesis is complex and is primarily thought to be an immune response mediated by immunoglobulin E(IgE)or T lymphocytes.Currently,one of the main pathogenic mechanisms of allergic inflammation is thought to be the T helper cell(Th2)-dominated hypersensitivity reaction,but little is known about other upstream channels of allergy.Emerging studies have revealed new cellular and molecular mechanisms by which the epithelium activates typeⅡinnate lymphoid cell(ILC2)through the production of pro-allergic cytokines,eg.interleukin(IL)-33,thymic stromal lymphopoietin(TSLP),etc.that in turn modulate the Th2 response.Furthermore,it was concluded that the type 2 immune response driven by ocular surface innate immunity is dependent on the involvement of IL-33,TSLP,basophils,and ILC2 in a mouse model of conjunctivitis induced by papain-impregnated contact lenses.At present,the mechanism of action of ILC2 and epithelial pro-allergic cytokines(IL-33,TSLP,etc.)in the pathogenesis of AC has not been fully elucidated.Therefore,the current status of research on ILC2 and their upstream molecules in the pathogenesis of allergic conjunctivitis was reviewed in this paper.

关 键 词：过敏 结膜炎 辅助型T细胞2 Ⅱ型固有淋巴细胞 白细胞介素-33 胸腺基质淋巴细胞生成素 

分 类 号：R777.31[医药卫生—眼科]