喉神经内分泌肿瘤26例临床病理特征及生存分析  

Clinicopathologic and survival analysis of laryngeal neuroendocrine neoplasm in 26 cases

作　　者：谢枫 许贞菊[1] 吴策 刘杰[1] 臧传善[1] 张龙宵 韩敏[1] XIE Feng;XU Zhenju;WU Ce;LIU Jie;ZANG Chuanshan;ZHANG Longxiao;HAN Min(Department of Otorhinolaryngology&Head and Neck Surgery,The Affiliated Hospital of Qingdao University,Qingdao 266003,Shandong,China;Department of Pathology,The Affiliated Hospital of Qingdao University,Qingdao 266003,Shandong,China)

机构地区：[1]青岛大学附属医院耳鼻咽喉头颈外科,山东青岛266003 [2]青岛大学附属医院病理科,山东青岛266003

出　　处：《山东大学耳鼻喉眼学报》2025年第2期79-86,共8页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：目的 探讨喉神经内分泌肿瘤的临床病理特征并进行生存分析,以期为临床诊疗提供有益的参考。方法 回顾性收集26例喉神经内分泌肿瘤患者的临床资料并对其临床病理特征并进行总结,使用Kaplan-Meier分析和Cox风险回归模型对喉神经内分泌肿瘤进行生存分析。结果 分化良好的喉神经内分泌肿瘤最为多见,BMI、肿瘤大小和Ki-67标记指数在分化程度不同的喉神经内分泌肿瘤患者间差异有统计学意义。喉神经内分泌肿瘤的总体5年总生存率仅为43.2%,预后较差。多因素分析显示,淋巴结转移、高Ki-67标记指数和远处转移是影响患者总生存率的独立危险因素。结论 不同分化程度的喉神经内分泌肿瘤具有不同的临床病理特征。淋巴结转移、Ki-67标记指数和远处转移是影响总生存率重要因素。Objective The objective of this study was to investigate the clinicopathologic characteristics of laryngeal neuroendocrine neoplasm and to conduct a survival analysis,with the aim of providing a valuable reference for clinical diagnosis and treatment.Methods A retrospective study of clinical data was conducted for a total of 26 patients diagnosed laryngeal neuroendocrine neoplasm.The clinical data was then grouped for the purpose of comparison.Survival analysis was perfoemed using both Kaplan-Meier analysis and Cox proportional-hazards regression models.Results Laryngeal neuroendocrine neoplasm(LNN)was most prevalent in the well-differentiated cases,and significant disparities were observed between the two groups with respect to the body mass index(BMI),tumour size,and Ki-67 labeling index.The 5-year overall survival rate for LNN was 43.2%,signifying a poor prognosis.Multifactorial analysis showed that lymph node metastasis,high Ki-67 labeling index and distant metastasis were independent risk factors affecting patients'overall survival rate.Conclusion Laryngeal neuroendocrine neoplasms manifesting diverse differentiation patterns exhibit distinct characteristics.The most significant factors affecting the overall survival rate are the Ki-67 labeling index,the presence of distant metastasis,and lymph node metastasis.

关 键 词：喉癌 神经内分泌肿瘤 生存分析 KI-67 

分 类 号：R739.65[医药卫生—肿瘤]