CD28和PD-1在自发性脑出血预后中的研究进展  

Research progress of CD28 and PD-1 in the prognosis of spontaneous intracerebral hemorrhage

作　　者：沈俊杰 蔡勇 钟兴明 SHEN Junjie;CAI Yong;ZHONG Xingming(Departments of Neurosurgery,the First Affiliated Hospital of Huzhou University(First People’s Hospital of Huzhou),Huzhou 313000,China)

机构地区：[1]湖州师范学院附属第一医院神经外科,浙江湖州313000

出　　处：《广州医药》2025年第4期446-451,522,共7页Guangzhou Medical Journal

基　　金：浙江省医药卫生科技计划项目(2021KY1096)。

摘　　要：自发性脑出血(SICH)是脑卒中的一种常见形式,其预后通常较差,因此早期评估和调节患者出血后的免疫状态至关重要。免疫检查点是评估T淋巴细胞活跃性和增殖状态的关键指标,监测这些检查点有助于预测脑出血患者的预后。程序性死亡蛋白1(PD-1)和细胞分化抗原28(CD28)作为两个典型的免疫检查点,它们在脑出血预后评估中的应用正逐渐成为研究的热点。该文综述了脑出血后机体免疫状态的变化,以及PD-1和CD28在脑出血后评估和治疗中的研究进展。Spontaneous intracerebral hemorrhage(SICH)is a common cause of stroke,with specific outcomes often being poor.Therefore,early assessment and modulation of the immune status after hemorrhage are of critical importance.Immune checkpoints serve as key indicators for assessing the activation and proliferation of T cells,and monitoring these checkpoints can help to predict the outcomes of patients with intracerebral hemorrhage.PD-1(programmed death 1)and CD28(Cluster of Differentiation28)are two representative immune checkpoints,and their use in prognostic assessment after intracerebral hemorrhage is becoming a focus of research.This article reviews the changes in the immune state of the body after intracerebral hemorrhage,as well as the research progress on the use of PD-1 and CD28 in the evaluation and treatment following intracerebral hemorrhage.

关 键 词：自发性脑出血 免疫检查点 PD-1 CD28 脑出血后免疫抑制 

分 类 号：R743.3[医药卫生—神经病学与精神病学]