放疗对抗肿瘤免疫的影响:从基础到临床  

Impacts of radiotherapy on anti-tumor immunity:a comprehensive review from the fundamental to the clinical

作　　者：文英美 夏锦雄 王园园 姚颐[1] Wen Yingmei;Xia Jinxiong;Wang Yuanyuan;Yao Yi(Cancer Center,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院肿瘤中心,武汉430060

出　　处：《国际肿瘤学杂志》2025年第4期231-236,共6页Journal of International Oncology

基　　金：北京华康公益基金会恶性肿瘤诊治能力提升工程项目(EXZL-GX-012)。

摘　　要：放疗在肿瘤的治疗中占据重要地位,除可直接引起肿瘤细胞DNA损伤、诱导细胞凋亡外,还参与调节全身免疫状态。越来越多的证据表明,放疗可重塑肿瘤免疫微环境(TIME),逆转免疫抑制状态,从而有利于增强抗肿瘤作用,并在与免疫检查点抑制剂联合应用时表现出更强的免疫反应和治疗获益。以肺癌为例探讨放疗对TIME及抗肿瘤免疫的影响和可能机制,可为优化肺癌治疗策略提供科学依据。Radiotherapy is a crucial component of the treatment of tumors.In addition to directly causing DNA damage in tumor cells and inducing cell apoptosis,radiotherapy is also involved in the regulation of systemic immune status.Increasing evidence indicates that radiotherapy can remodel the tumor immune microenvironment(TIME)and reverse the immunosuppressive state,thereby enhancing anti-tumor effects and demonstrating stronger immune responses and therapeutic benefits when combined with immune checkpoint inhibitors.Taking lung cancer as an example to explore the impacts and potential mechanisms of radiotherapy on the TIME and anti-tumor immunity,which can provide a scientific basis for optimizing the treatment strategies of lung cancer.

关 键 词：放射疗法 肺肿瘤 肿瘤微环境 免疫疗法 免疫调节 

分 类 号：R730.55[医药卫生—肿瘤]