果糖二磷酸醛缩酶A在肺癌中的研究进展  

Progress in the study of fructose-bisphosphate aldolase A in lung cancer

作　　者：芦兵 熊思玉 蒋汶宏 俞婷婷 Lu Bing;Xiong Siyu;Jiang Wenhong;Yu Tingting(Department of Pulmonary Medicine,Third Clinical Medical College(Cancer Hospital)of Xinjiang Medical University,Urumqi 830011,China)

机构地区：[1]新疆医科大学第三临床医学院(肿瘤医院)肺内科,乌鲁木齐830011

出　　处：《国际肿瘤学杂志》2025年第4期242-245,共4页Journal of International Oncology

基　　金：新疆维吾尔自治区自然科学基金(2022D01C522)。

摘　　要：葡萄糖代谢重编程过程中的多种代谢酶及信号分子参与肺癌的发生发展,研究这些代谢酶及信号分子是肺癌临床诊疗的热点和方向之一。果糖二磷酸醛缩酶A(ALDOA)是葡萄糖代谢重编程中一个重要的催化酶,其异常表达与肺癌发生发展存在错综复杂的联系,系统探讨ALDOA在肺癌代谢中的作用,可为预测肺癌转移、预后以及耐药后的治疗提供新思路。Various metabolic enzymes and signaling molecules in the reprogramming process of glucose metabolism are involved in the occurrence and development of lung cancer.The study of these metabolic enzymes and signaling molecules is one of the hot spots and directions in the clinical diagnosis and treatment of lung cancer.Fructose-bisphosphate aldolase A(ALDOA)is an important catalytic enzyme in the reprogramming of glucose metabolism,and the abnormal expression of ALDOA is intricately related to the occurrence and development of lung cancer.Systematically exploring of the role of ALDOA in lung cancer metabolism may provide new ideas for predicting the metastasis,prognosis,and treatment after drug resistance of lung cancer.

关 键 词：肺肿瘤 果糖-二磷酸醛缩酶 预后 

分 类 号：R734.2[医药卫生—肿瘤]