线粒体分裂/融合动态变化在变应性疾病中的研究进展  

Advances in research on mitochondrial fission and fusion dynamics in allergic diseases

作　　者：何开元 周龙云 陈旭青 吴拥军[1,3] HE Kai-yuan;ZHOU Long-yun;CHEN Xu-qing;WU Yong-jun(the First Clinical Medical College,Nanjing University of Traditional Chinese Medicine,Nanjing 210046,China;the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China;the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学第一临床医学院,江苏南京210046 [2]南京医科大学第一附属医院,江苏南京210029 [3]南京中医药大学附属医院,江苏南京210023

出　　处：《中国药理学通报》2025年第5期820-824,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金面上项目(No 82374527);国家自然科学青年科学基金项目(No 82205148)。

摘　　要：线粒体分裂/融合动态变化指线粒体分裂与线粒体融合两种运动方式,来自内外源的刺激促进线粒体动态变化的发生,调控细胞功能以应答生理及病理变化。该文系统性回顾相关文献,从生理病理特征概述线粒体分裂/融合动态变化;围绕离子稳态、氧化还原平衡、能量代谢、程序性死亡等功能性改变阐述线粒体分裂/融合动态变化内涵;并基于此,以变应性疾病中关键细胞组分为中心,论述线粒体分裂/融合动态变化功能改变对变应性疾病的影响。从线粒体分裂/融合动态变化概念、线粒体分裂/融合动态变化的功能内涵、线粒体分裂/融合动态变化对变应性疾病关键细胞组分的影响这一递进关系中将线粒体分裂/融合动态变化与变应性疾病进行链接,构建线粒体分裂/融合动态变化调节多元化细胞组分影响变应性疾病进展的网络化图谱,以期为变应性疾病的机制研究及系统治疗提供引导。Mitochondrial dynamics refer to two modes of movement:mitochondrial fission and mitochondrial fusion.Stimulation from internal and external sources promotes the occurrence of mitochondrial dynamic changes,supporting cellular functional changes to adapt to physiological and pathological changes.This article systematically reviews relevant literature,providing an overview of the dynamic changes in mitochondrial fission/fusion from both physiological and pathological perspectives.It summarizes the essence of these changes by highlighting functional alterations,including ion homeostasis,redox balance,energy metabolism,and programmed death signaling,and reveals the underlying mechanisms of action.Additionally,by focusing on key cellular components in allergic diseases,it discusses the impact of functional alterations in mitochondrial dynamic division/fusion on allergic diseases.Progressively examining the concept,functional alterations,and impact on allergic diseases,this study establishes a connection between mitochondrial fission/fusion dynamics and key cellular components of allergic diseases.It constructs a networked map that outlines how these dynamics modulate the progression of allergic diseases through diverse cellular components,aiming to guide mechanistic studies and systematic treatments for these diseases.

关 键 词：线粒体动力学 线粒体 超敏反应 变应性疾病 肥大细胞 2型天然淋巴细胞 

分 类 号：R-05[医药卫生] R329.24R331.125R593.1