脑源性神经营养因子DNA甲基化与抑郁  

Advances in DNA methylation of brain-derived neurotrophic factor and depression

作　　者：廖紫云 王孟雨[2] 乔靖怡[3] 张润 刘培东 陈新旺[1] LIAO Zi-yun;WANG Meng-yu;QIAO Jing-yi;ZHANG Run;LIU Pei-dong;CHEN Xin-wang(School of Acupuncture and Tuina,The Third Affiliated Hospital of Henan University of Chinese Medicine,Henan University of Chinese Medicine,Zhengzhou 450046,China;School of Rehabilitation Medicine,Henan University of Chinese Medicine,Zhengzhou 450046,China;School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学第三附属医院针灸推拿学院,河南郑州450046 [2]河南中医药大学康复医学学院,河南郑州450046 [3]河南中医药大学药学院,河南郑州450046

出　　处：《中国药理学通报》2025年第5期825-829,共5页Chinese Pharmacological Bulletin

基　　金：国家自然基金青年基金项目(No 82305417);河南省科技攻关项目(No 232102311217);河南省中医药科学研究专项课题(No 2022ZY2061)。

摘　　要：抑郁症是一种异质性精神疾病,遗传易感性和环境因素之间的相互作用在其发病过程中扮演着关键角色。该病的具体机制仍需深入研究与阐释,但目前已有广泛共识认为,表观遗传标记对其作用机制具有重要影响。脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)的DNA甲基化,不仅被视为一种有前景的病理学表观遗传生物标志物,还可能有助于预测抗抑郁药的疗效。该文综述了BDNF的基因结构及其DNA甲基化调控机制,同时分析了抑郁症患者及动物模型中该因子DNA甲基化的变化情况,旨在为临床研究提供新的思路和理论支撑。Depression is a heterogeneous mental disorder in which the interaction between genetic susceptibility and environmental factors plays a key role in its pathogenesis.Although the specific mechanisms of the disease still need to be thoroughly studied and elucidated,there is now a broad consensus that epigenetic markers have a central influence on its mechanism of action.DNA methylation of brain-derived neurotrophic factor(BDNF)is not only regarded as a promising epigenetic biomarker of pathology,but may also help predict the efficacy of antidepressants.In this paper we reviewed the gene structure of BDNF and its DNA methylation regulation mechanism,and also analyzed the changes of DNA methylation of this factor in depression patients and animal models,aiming to provide new ideas and theoretical support for clinical research.

关 键 词：脑源性神经营养因子 DNA甲基化 基因结构 抑郁 启动子 外显子 

分 类 号：R342.3[医药卫生—基础医学] R394.2R749.42