亚砷酸钠对几个肿瘤相关基因表达水平影响的研究  

The Study on Several Tumor Genes Expression Caused by NaAsO_2 in Liver Cells

作　　者：姚华[1] 王国荃[1] 朱滨[2] 孙悦[2] 景丰香[2] 赵建龙[2] 

机构地区：[1]新疆医科大学公共卫生学院环境卫生教研室,新疆乌鲁木齐830054 [2]中国科学院上海冶金研究所,上海200050

出　　处：《地方病通报》2002年第4期1-4,共4页Endemic Diseases Bulletin

基　　金：国家自然科学基金 (地区联合 )资助项目 (399690 0 4 )

摘　　要：为探讨砷作用的分子遗传机制 ,采用寡核苷酸芯片和 c DNA芯片两种方法来研究砷对已知基因 (c- myc和 p5 3)和未知基因表达水平的影响 ,结果表明亚砷酸钠造成肝细胞中 p5 3抑癌基因、人肿瘤抑制基因表达增强 ,c- myc癌基因和解偶联蛋白基因表达减弱 ,说明亚砷酸钠在正常人肝细胞中表现出抗癌效应并能促进能量储存。Oligonucleotide microarray and cDNA microarray were used to research expression level of the known and unknown genes of NaAsO 2 for exploring the molecular mechanism of NaAsO 2. Results showed NaAsO 2 induced p53 and hTSG101 gene expression, and inhibited C myc and UCP 2 gene expression in human liver cells. That meant NaAsO 2 appeared anti cancer effect and promoted the store of energy in human liver cells.

关 键 词：亚砷酸钠 肿瘤相关基因 基因表达 

分 类 号：R73－36[医药卫生—肿瘤]