蒙脱石治疗消化性溃疡50例  

Smectite in treatment of peptic ulcer in fifty patients

作　　者：程家欣[1] 程玲[1] 余传定[1] 戴一杨[1] 管小娟[1] 郑培奋[1] 施向凡[1] 陈新宇[1] 

机构地区：[1]浙江医院消化科,浙江杭州310013

出　　处：《中国新药与临床杂志》2003年第1期40-42,共3页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :评价蒙脱石治疗消化性溃疡的临床疗效与安全性。方法 :蒙脱石组 (5 0例 )患胃溃疡 18例和十二指肠球部溃疡 32例 [男性 35例 ,女性 15例 ,年龄 (5 0±s 11)a],用蒙脱石散剂 3g ,tid ,疗程 4wk。胶态次枸橼酸铋组 (30例 )患胃溃疡 12例和十二指肠球部溃疡 18例 [男性 2 0例 ,女性 10例 ,年龄(48± 13)a],用胶态次枸橼酸铋胶囊 110mg ,tid ,疗程 4wk。结果 :蒙脱石组消化性溃疡愈合率为80 % ,总有效率为 90 % ,胶态次枸橼酸铋组消化性溃疡愈合率为 6 0 % ,总有效率为 77% ;2组愈合率、总有效率相比 ,差异无显著意义 (P >0 .0 5 ) ,2组疗效的比较差异亦无显著意义 (P >0 .0 5 )。 2组不良反应均轻 ,分别为 4 %和 3% (P >0 .0 5 )。结论 :蒙脱石治疗消化性溃疡有较好疗效 ,且不良反应少而轻微 。AIM: To evaluate the therapeutic effect and safety of smectite powder in treating peptic ulcer. METHODS: Thirty two patients with duodenal ulcer and eighteen patients with gastric ulcer(M 35, F 15; age(50± s 11) a)were treated with smectite 3 g tid for 4 wk. Another eighteen patients with duodenal ulcer and twelve patients with gastric ulcer(M 20, F 10; age(48±13) a)were treated with colloidal bismuth subcitrate tablets 110 mg tid for 4 wk. RESULTS: The ulcer healing rate of peptic ulcer was 80 % and 60 % in smectite group and colloidal bismuth subcitrate group, respectively. The total effective rate of peptic ulcer was 90 % and 77 % in smectite group and colloidal bismuth subcitrate group, respectively. There was a significant difference between two groups by Ridit analysis ( P >0.05). CONCLUSION: Smectite is effective and safe in treating peptic ulcer.

关 键 词：蒙脱石 胶态次枸橼酸铋 消化性溃疡 治疗 

分 类 号：R573.105[医药卫生—消化系统]