A novel mediator of the amyloid-βneurotoxicity in Alzheimerls disease:Ubiquitin conjugating enzyme E2-25K/Hip-2 as upstream of caspase-12  

作　　者：YUHYUNSONG JOOYONGLEE 等 

机构地区：[1]DepartmentofLifeScience,KwangjuInstituteofScienceandTechnology,Kwangju500－712,Korea [2]UniversityofUlsanCollegeofMedicine,Seoul138－736,Korea

出　　处：《Cell Research》2002年第3期288-288,共1页细胞研究（英文版）

摘　　要：Accumulation of amyloid-β(Aβ) and its neurotoxicity are regarded as a major factor promoting neu-ronal degeneration in Alzheimer's disease (AD). Upon investigation of Aβtoxicity using DNA microarray, we isolated ubiquitin conjugating enzyme E2-25K/Hip-2 as a mediator of Aβ toxicity. Here we show that expression of E2-25K/Hip-2 was strongly up-regulated in the cultured cortical neurons exposed to Aβ1-42 in vitro and in vulnerable neurons surrounding senile plaques of the brain derived from AD patients and Tg2576 Alzheimer's mice. Aβ1-42-induced neurotoxicity, accumulation of ubiquitin conjugates, and decrease of the proteasome activity were mediated by ubiquitin ligase activity of E2-25K/Hip-2. Aβ-induced

关 键 词：淀粉样蛋白-β 神经毒性 早老性痴呆 介导因子 遍在蛋白结合酶 E2-25K/Hip-2 CASPASE-12 

分 类 号：R749.16[医药卫生—神经病学与精神病学]