PML Gene, arsenic and apoptosis of leukemic cells  

出　　处：《Cell Research》2002年第3期288-289,共2页细胞研究（英文版）

摘　　要：Acute promyelocytic leukaemia (APL) has been attracting a wide interest far beyond hematological field in the last dozen years due to the presence of specific chromosome tranlocations and clinical responsibility to all-trans retinoic acid (ATRA) by differentiation induction as well as to arsenic trioxide (ATO). Most (】95%) APL patients carry specific chromosome translocation t(15;17), which leads to discovery of PML gene on chromosome 15. Such a translocation causes the fusion of PML to retinoic acid

关 键 词：白血病细胞 细胞凋亡 PML基因 三氧化二砷 

分 类 号：R733.7[医药卫生—肿瘤] R979.[医药卫生—临床医学]