杏仁核和扣带回毁损对Ⅰ型精神分裂症患者脑脊液单胺递质的影响  

Influence of media subnucleus of amygdala and front part of callosal gyrus lesion with stereotactic techniques on monoamine transmitters in schizophrene's cerebral spinal fluid

作　　者：李拴德[1] 李涛[1] 王晓峰[1] 姜克明[1] 尹乾坤[1] 杨来启[2] 吴兴曲[2] 刘光雄[2] 

机构地区：[1]解放军第三医院神经外科,宝鸡721004 [2]解放军第三医院精神科,宝鸡721004

出　　处：《西安交通大学学报（医学版）》2002年第6期598-599,共2页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：全军临床高新技术重大项目 ;全军医学科研"十五"计划面上项目A类 (No .0 1MA0 19)

摘　　要：目的　研究立体定向联合毁损杏仁核内侧核群和扣带回前区对Ⅰ型精神分裂症患者脑脊液内单胺类递质的影响 ,探讨手术影响单胺类递质水平及手术治疗精神分裂症的机理。方法　用立体定向技术射频毁损Ⅰ型精神分裂症患者杏仁核内侧核群和扣带回前区 ,用高效液相色谱法 (HLPC)测定手术前后患者脑脊液DA、5 HT、NE的含量 ,对含量的变化进行统计学处理。结果　治疗前不同性别、年龄及病程之间DA、5 HT、NE未见明显差异(P >0 .0 5 ) ;治疗前DA明显高于对照组 ,治疗后DA下降 ,与手术前相比有显著性差异 (P <0 .0 5 ) ;治疗前 5 HT和NE明显低于对照组 ,治疗后升高 ,但仍低于对照组 (P >0 .0 5 )。结论　毁损杏仁核内侧核群和扣带回前区可以使Ⅰ型精神分裂症患者脑脊液内DA水平升高 ,5 HT和NE水平降低 。Objective To study the changes of monoamine transmitters in spinal fluid of patients with schizophrenia Ⅰ after damaging media subnucleus of amygdala and front part of callosal gyrus with stereotactic techniques. Methods The different content of DA, 5 HT and NE in spinal fluid was analysised between and postoperative by HLPC. Results There was no difference in different sex, age and course( P >0.05); DA was higher than the contrast and reduced after treatment ( P <0.05); 5 HT increased after treatment; NE was lower than the control before treatment and increased after treatment( P >0.05).Conclusion Lesion of media subnucleus of amygdala and front part of callosal gyrus can increase DA, reduce 5 HT in cerebral spinal fluid of patients with schizophrenia Ⅰ.

关 键 词：杏仁核 扣带毁损 Ⅰ型精神分裂症 脑脊液 单胺递质 扣带回前区 

分 类 号：R749.3[医药卫生—神经病学与精神病学]