抵当汤改良方对实验性动脉粥样硬化家兔抗氧化活性及神经酰胺含量的影响  

Effects of Antioxidation and Ceramide of Improved Prescription of Didang-tang (IPDT) on Exprimental Atherosclerosis Rabbits.

作　　者：黄河清[1] 刘培庆[1] 陶莎[2] 

机构地区：[1]中山大学药学院,广东广州510080 [2]中山大学中山医学院,广东广州510080

出　　处：《中国中药杂志》2002年第12期942-944,共3页China Journal of Chinese Materia Medica

基　　金：广东省自然科学基金资助项目(No.001399)

摘　　要：目的:观察抵当汤改良方对实验性动脉粥样硬化家兔抗氧化活性及神经酰胺含量的影响。方法:运用微量快速法检测血浆超氧化物歧化酶活性,运用改良八木国夫法检测血浆丙二醛含量,运用薄层扫描法检测主动脉神经酰胺含量。结果:抵当汤改良方对实验性动脉粥样硬化家兔能有效提高血浆超氧化物歧化酶活性,降低血浆丙二醛含量,降低主动脉神经酰胺脂质含量。结论:抵当汤改良方抗实验性动脉粥样硬化作用与提高机体抗氧化酶活性及降低神经酰胺含量有关。Objective: To observe the effects of antioxidation and ceramide content of improved prescription of Didang-tang (IPDT) on exprimental atherosclerosis(AS) rabbits. Method:Plasm Superoxide Dismutase(SOD) activity was detected with micro-content fast detecting method, Plasm Malondialdehyde (MDA) content with improved BaMuGuoFu method, and Aortic Ceramide (CER) content with thinlayer scannig. Result: IPDT could effectivly improve plasma SOD activity and decrease plasma MDA contrnt and decrease aortic CER content. Conclution:IPDT on exprimental AS is related to the improvement of antioxidation and decrease of CER content.

关 键 词：实验性动脉粥样硬化 抗氧化活性 神经酰胺 抵当汤改良方 AS 

分 类 号：R285.5[医药卫生—中药学]