鼻咽癌遗传易感性与醌氧化还原酶基因多态性的关系  

Quinone oxidoreductase gene polymorphism and genetic susceptibility to nasopharyngeal carcinoma

作　　者：吴德华[1] 

机构地区：[1]第一军医大学南方医院放疗科,广东广州510515

出　　处：《第一军医大学学报》2002年第12期1126-1127,1130,共3页Journal of First Military Medical University

摘　　要：目的探讨醌氧化还原酶基因NQO1的cDNA 609位碱基C→T点突变所致的基因多态性位点是否与鼻咽癌遗传易感性有关。方法采用聚合酶链反应-限制性片断长度多态性技术(PCR-RFLP)分析了120例鼻咽癌病人与120例健康对照者NQO1的基因多态性。结果经字2检验,基因型分布在鼻咽癌和对照组之间有显著差异(P<0.01),C/T、T/T基因型频率鼻咽癌组高于对照组,C/C基因型频率鼻咽癌组低于对照组。等位基因频率在鼻咽癌和对照组有显著性差异(P<0.01),T等位基因频率鼻咽癌组高于对照组。结论NQO1基因cDNA 突变T609等位基因可能是鼻咽癌的遗传易感性有关危险因素之一。Objectives To ascertain whether the point mutation of cDNA609 C to T of quinone oxidoreductase (NQO1) gene is associated with the genetic susceptibility to nasopharyngeal carcinoma. Methods Polymerase chain reaction-restriction fragment length polymorphism was employed to assess the polymorphism of NQO1 genes both in 120 patients with nasopharyngeal carcinoma and 120 healthy subjects matched for age, gender and origin. Results The allelic frequency of mutant T allele of NQO1 gene was significantly higher in patients with nasopharyngeal carcinoma than in the healthy subjects (P<0.05), and the individuals with T allelic genotype of NQO1 gene were at greater risk to develop nasopharyngeal carcinoma. Conclusion The cDNA 609 T allele of NQO1 gene is very likely to be associated with the genetic susceptibility to nasopharyngeal carcinoma.

关 键 词：鼻咽癌 遗传易感性 醌氧化还原酶 基因多态性 鼻咽肿瘤 病因学 NAD(P)H脱氢酶 基因频率 基因型 

分 类 号：R739.63[医药卫生—肿瘤]