养血清脑颗粒对典型偏头痛患者MEP和SPECT的影响及临床意义  

The Effect and Clinical Significance of Yangxue Qingnao Granules on MEP and SPECT of Typical Migraine Patients

作　　者：杨军[1] 董为伟[1] 

机构地区：[1]重庆医科大学附属第一医院神内科,重庆市400016

出　　处：《中国药房》2002年第12期741-742,共2页China Pharmacy

摘　　要：目的 :观察养血清脑颗粒对典型偏头痛患者经颅磁刺激 (MEP)和脑血流成像(SPECT)的影响及临床意义。方法 :各15例典型偏头痛患者口服养血清脑颗粒和安慰剂 ,共20天。分别于治疗前、后做MEP ,并与15例健康志愿者作对照 ;养血清脑颗粒组中的5例患者于治疗前、后做SPECT。结果 :治疗前MEP的刺激阈值低于治疗后 ,且皮层至小指展肌传导时间 (CMCT)较治疗后长 ,而安慰剂组无改变 ;5例SPECT的定性分析显示均有不同程度的低灌注区 ,治疗后其灌注缺损显著改善。结论 :养血清脑颗粒能够有效治疗典型偏头痛 。OBJECTIVE:To observe the effect and clinical significance of Yangxue Qingnao granules(YQG) on MEP and SPECT of typical migraine patients METHODS:15 typical migraine patients took YQG for 20 days and received MEP before and after treatment,taking 15 healthy volunteers as control 5 patients in treatment group underwent SPECT before and after treatment RESULTS:The stimulating threshold value of MEP before treatment was lower than that after treatment and CMCT was longer than that after treatment The stimulating threshold values of the healthy volunteers had no changes and were higher than those of the typical migraine patients The qualitative analysis of the 5 SPECT showed that hypoperfusion areas occured at varying degrees and perfusion defect had got remarkable improvement after treatment CONCLUSION:YQG can effectively treat typical migraine and control it's attack

关 键 词：扩展性皮质抑制 颅磁刺激 脑血流成像 养血清脑颗粒 典型偏头痛 MEP SPECT 临床意义 

分 类 号：R747.2[医药卫生—神经病学与精神病学] R277.[医药卫生—临床医学]