原发性肝癌sICAM-1、血清NO检测的临床意义  

The significance of detection of sICAM-1、No in plasma of primary liver cancer

作　　者：潘晓华[1] 吴泰璜[1] 穆庆岭[1] 苏忠学[1] 吴亚光[1] 

机构地区：[1]山东省立医院,山东济南250021

出　　处：《山东医药》2002年第24期4-6,共3页Shandong Medical Journal

摘　　要：采用 EL ISA与硝酸还原酶法检测原发性肝癌 (primary liver cancer,PL C)患者的血清细胞间粘附分子 - 1(s ICAM- 1)与血清一氧化氮 (NO)含量。 PL C患者的 s ICAM- 1与乙型肝炎后肝硬化 (P<0 .0 1)、慢性乙型肝炎患者 (P<0 .0 1)及健康对照组 (P<0 .0 1)比较有显著性差异 ,随 PL C临床分期逐渐升高。 PL C患者血清 NO水平与乙型肝炎后肝硬化无统计学差异 (P>0 .0 5 ) ,与慢性乙型肝炎及健康对照有显著性差异 (P<0 .0 1) ,PL C血清 NO与 s ICAM- 1呈正相关 (r=0 .5 97)。认为 :PL C高水平的 s ICAM- 1主要来自肿瘤细胞 ,监测 s ICAM- 1有助于了解 PL C病情进展、瘤负荷。 s ICAM- 1调高了 NO的产生 ,但肝癌细胞产生的 NO在 PL C患者血清To research the role of sICAM 1 and NO in occurrence and progress of primary liver cancer(PLC),serum ICAM 1(sICAM 1) and NO in serum of PLC patients,were detected by nitric acid enzyme deoxidization and enzyme linked immuoadsorbent assay(ELISA) respectively.The Results showed level of sICAM 1 significantly increased in PLC compared with liver cihrrosis( LC)(P<0.01),chronic hepatitis(CH)(P<0.01) or healthy contrast(P<0.01). There was significant difference betweenⅠstage+Ⅱstage and Ⅲ stage (P<0.01),Ⅳ stage (P<0.01). The serum NO levels of PLC had no difference with that LC (P>0.05) .Levels of serum NO correlated with levels of sICAM 1 positively in PLC. This suggests high level sICAM 1 derived mostly from tumor cell in PLC.Surveying of sICAM 1 was making for realizing the state of illness,tumor burden for PLC sICAM 1 enhanced production of NO,NO produced by tumor was not major component in serum NO of PLC.

关 键 词：原发性肝癌 细胞间粘附分子-1 一氧化氮 PLC 

分 类 号：R735.7[医药卫生—肿瘤]