可溶性血管细胞粘附分子-1在妊娠肝内胆汁淤积症患者中的变化及意义  

The changes of sVCAM-1 in intrahepatic cholestasis of pregnancy(ICP)

作　　者：方彩云[1] 张丽萍[1] 方孝梅[1] 

机构地区：[1]湖北省郧阳医学院附属太和医院,十堰市442000

出　　处：《右江医学》2002年第6期483-484,共2页Chinese Youjiang Medical Journal

摘　　要：目的 :了解可溶性血管细胞粘附分子 1(sVCAM 1)在妊娠肝内肝汁淤积症 (ICP)患者母血、脐血的变化 ,揭示ICP可能的发病机制。方法 :采用ELISA方法检测sVCAM 1的浓度。结果 :ICP患者血清、脐血中sVCAM 1的浓度明显高于正常孕妇组 (P<0 .0 1) ;两组孕妇产后 1周母血sVCAM 1逐渐降到正常非孕水平 (P>0 .0 5 )。结论Objective:To investigate circulating levels of vascular cell adhesion molecule 1 in the peripheral and uteroplacental circulations of ICP.To reveal the pathogenesis of ICP.Methods:ELISA was employed in detecting the concentration of sVCAM 1.Results:Significantly higher level of sVCAM 1 was detected in the uteroplacent and peripheral circulation of ICP women by comparison with normal pregnancy(P<0.01),and the markedly decreased to normal in one week after delivery (P>0.05).Conclusion:our research suggests that abnormal expression of adhesion molecules may play a role in the pathogenesis of ICP.

关 键 词：可溶性血管细胞粘附分子-1 妊娠肝内胆汁淤积症 妊娠并发症 ICP 发病机制 母血 脐血 

分 类 号：R714.255[医药卫生—妇产科学]