原发性肝癌组织及血清中豌豆凝集素结合型甲胎蛋白含量对照研究  

Alpha-fetoprotein Reactive to Pisum Sativum Agglutinin in Liver Tumor Tissues and Sera from Patients with Primary Liver Cancer

作　　者：屠振兴[1] 殷正丰[1] 吴孟超[1] 崔贞福[1] 胡韪[1] 

机构地区：[1]第二军医大学肝胆外科研究所,200433

出　　处：《第二军医大学学报》1992年第5期423-425,共3页Academic Journal of Second Military Medical University

摘　　要：作者检测了25例原发性肝癌、非癌肝组织以及外周血中豌豆凝集素结合型甲胎蛋白(AFP-R-P)含量,分别为41±26％、30±27％和36±25％。≤3cm、包膜完整、没有向周围肝组织浸润性生长、无血管癌栓的肝癌组织中AFP-R-P含量较低,患者术后生存期较长。结果提示,AFP-R-P主要由恶性行为较高的肝癌细胞所分泌,它直接或经血路向周围肝组织弥散,同时进入外周血循环,使血清中AFP-R-P含量升高。Alpha-fetoprotein reactive to pisum sativum agglutinin (AFP-R-P) in liver tumor tissues, surrounding noncancerous tissues and peripheral blood from 25 cases of primary liver cancer were measured. Their medium and standard deviation were 41 ±26%, 30±27% and 36±25%, respectively. AFP-R-P levels were lower in the tumors with a diameter of less than 3cm, intact capsule, no invasion of surrounding liver tissues and no tumor thrombus. The patients with lower AFP-R-P levels had a longer survival. The results indicate that AFP-R-P is secreted mainly by tumor cells possessing more malignant behaviour, diffused directly in surrounding liver tissues and entered into peripheral blood, resulting in elevated serum AFP-R-P.

关 键 词：凝集素 甲胎蛋白 肝肿瘤 

分 类 号：R735.702[医药卫生—肿瘤]