葡萄膜黑色素瘤病理学特征与预后的关系  

Research on the relationship between pathological features of the uveal melanoma and prognosis

作　　者：郭琳洁[1] 吴中耀[2] 张胜[2] 陈家祺[2] 艾思明[2] 郑湖玲[2] 

机构地区：[1]深圳市眼科医院,518001 [2]中山大学中山眼科中心

出　　处：《中华病理学杂志》2002年第6期518-521,共4页Chinese Journal of Pathology

摘　　要：目的　探讨葡萄膜黑色素瘤病理学特征对患者预后估计的意义。方法　按改良Callender分类 ,对 115例病理样本常规病理形态检查 ,临床随访 ,应用SPSS统计软件包 ,进行生存曲线及回归分析。结果　葡萄膜黑色素瘤患者的平均生存时间分别为 ,类上皮型肿瘤 3 5 6± 2 1 5月 ,混合型肿瘤 63 7± 3 7 0月 ,梭形细胞型肿瘤 69 5± 3 6 5月 ,类上皮型肿瘤患者生存时间较短 ;患者生存时间与肿瘤的巩膜接触最大径 ,肿瘤的最大高度及肿瘤的浸润深度呈负相关。结论　类上皮型葡萄膜黑色素瘤恶性程度较其他两型高 。Objective To study the pathological features of uveal melanoma and to evaluate their influence on patients′ prognosis. Methods Paraffin embedded uveal melanoma tissues of 115 cases were examined using routine pathologic methods. Three histological types were classified according to the modified Callender system and patients were followed clinically. The data were done regression and survival analysis by SPSS statistic soft. Results The patient with epithelial cell type, mixed type, and spindle cell type uveal melanoma have different life times, the average life time is 35.6±21.5 months, 63.7±37.0 months, 69.5±36.5 months in turn, patients with epithelial uveal melanoma had shorter survival time than other two types. The survival time was negatively related to the largest diameter of contact area with the sclera, the largest height and the depth of tumor invasion to the sclera. Conclusions Epithelial uveal melanoma is more malignant than the other two types. Histological classification of this tumor combined with other pathologic features can indicate the patient′s prognosis.

关 键 词：葡萄膜黑色素瘤 病理学特征 预后 

分 类 号：R739.7[医药卫生—肿瘤]