抗癌药物马蔺子素的β-环糊精包络物研究  

STUDY ON THE INCLUSION COMPLEX OF IRISQUINONE WITH β-CYCLODEXTRIN

作　　者：宋俊峰[1] 何平[1] 王福民[2] 

机构地区：[1]西北大学分析科学研究所,陕西西安710069 [2]渭南师范学院,陕西渭南714000

出　　处：《药学学报》2002年第12期963-966,共4页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目 ( 2 9875 0 17)

摘　　要：目的　研究抗癌药物马蔺子素与 β 环糊精的主 客体包络行为。 方法　在悬汞电极上用循环伏安法考察β 环糊精不存在和存在时马蔺子素还原波的变化。结果　在 0 0 4mol·L- 1 KH2 PO4 Na2 HPO4(pH 6 8)近生理介质中 ,β 环糊精的引入使马蔺子素的还原波峰电流降低 ,峰电位正移。结论　电活性客体分子马蔺子素与主体分子 β 环糊精生成 1∶1的包络物。用“电流法”测得其形成常数Kf 值为 1 92× 10 3 L·mol- 1 。包络物的生成增强了马蔺子素的稳定性。AIM To study the host-guest inclusion behavior of anticancer drug irisquinone with β-cyclodextrin. METHODS The variance of the reduction ware of irisquinone in the absence and presence of β-cyclodextrin was examined by cyclic voltammetry at the hanging mercury drop electrode. RESULTS In 0.04 mol·L -1 KH 2PO 4-Na 2HPO 4 (pH 6.8) supporting electrolyte which was close to physiological condition, the introduction of β-cyclodextrin resulted in both decrease of reduction current and the positive shift of peak potential of reduction ware of irisquinone. CONCLUSION The electroactive guest molecule irisquinone was complexed with host molecule β-cyclodextrin to the formation of 1∶1 inclusion complex. The inclusion constant K f was 1.92×10 3 L·mol -1 by the electric current method. The formation of the inclusion complex enhanced the stability of irisquinone.

关 键 词：马蔺子素 Β-环糊精 包络物 循环伏安法 主-客体色络行为 马蔺子 

分 类 号：TQ460.72[医药卫生—药物分析学] R97[化学工程—制药化工]