血清异常IgG测定诊断肝硬变的初步报告  

Preliminary study of diagnosis of liver cirrhosis assay in serum abnormal IgG

作　　者：齐为民[1] 刘茂贤[1] 严家定 侯瑜[1] 梁国栋[2] 

机构地区：[1]唐都医院检验科 [2]唐都医院中心实验室

出　　处：《第四军医大学学报》1992年第4期287-289,共3页Journal of the Fourth Military Medical University

摘　　要：作者发现,用于测定血浆纤维蛋白原的125 g/L亚硫酸钠对肝硬变患者血清具有明显的沉淀反应,并建立了简便、微量、快速和不受黄疸干扰的定量透射比浊法.受检者661例中肝功能正常献血员300例,其异常IgG(ab-IgG)为0～180mg/L;非肝病患者100例为0～150 mg/L;以x+3S为阳性界限,138例各类肝炎43例阳性;肝癌21例中8例阳性;肝硬变90例阳性率为100％、特异性为80％.比较结果表明,ab-IgG对肝硬变的诊断优于A/G(84％),MAO(85％),IgG(64％),TTT(46％),ZnTT(54％)和蛋白电泳r带(89％)测定.亚硫酸钠沉淀物经初步鉴定为异常IgG.实践证明以往用125g/L亚硫酸钠测定血浆纤维蛋白原作为DIC的筛选指标并非可靠.This article reports the first time that a rapid microscale procedure for No2SO3 turibidity test (NaTT)of patients with liver cirrhosis. Test indicated that 300 cases of healthy subjects and 100 patients of non-hepatopathy were normal, the normal reference interval ranged from 0 to 180 mg/L and 0 to 150 mg/L (x±2S), respectively. Eight cases increased in 17 patients with primary liver neoplasms and only 43 cases increased in 138 patients with acute and chronic hepatitis, but 90 patients with liver cirrhosis, increased remarkably, had concentrations ranging from 340 to 2 540 mg/L (x + 3S), that means positive rate equal to 100%. The average within run precision (CV)for 20 samples was 3.4% and the between run was 5.2%. Evidently, this method is the most sensitive marker for liver cirrhosis at present.

关 键 词：IGG 肝硬变 诊断 

分 类 号：R575.204[医药卫生—消化系统]