金蚕宝对CCl_4所致实验性肝损伤的保护作用  

Hepatoprotective Activity of Jincanbao on CCl_4-induced Hepatic Damage in Mice

作　　者：陈智毅[1] 陈列辉[1] 李清兵[1] 吴娱明[1] 廖森泰[1] 姚锡镇[1] 

机构地区：[1]广东省农业科学院蚕业研究所,广州510610

出　　处：《蚕业科学》2002年第4期347-348,共2页ACTA SERICOLOGICA SINICA

摘　　要：应用四氯化碳 (CCl4 )化学性肝损伤动物模型 ,以肝功能为主要指标 ,研究以家蚕熟蚕粉和灵芝为主要材料的金蚕宝护肝制剂 (JCBH)对实验性肝损伤的保护作用。结果表明 ,金蚕宝护肝制剂和熟蚕粉均显著降低小鼠血液中谷丙转氨酶 (GPT)和谷草转氨酶 (GOT)的酶活力 (P <0 0 1) ,金蚕宝护肝制剂略优于熟蚕粉 ,但与阳性药联苯双酯和熟蚕粉相比 ,无显著性差异 (P >0 0 5 )。表明金蚕宝护肝制剂对化学性肝损伤有明显的保护作用。The hepatoprotective activity of JCBH(Jincanbao preparation for hepatoprotection),which is mainly made of PMS(powder of mature silkworm larva)and glossy ganoderma,was observed with aniaml model by CCl 4 induced hepatic damage.The results showed that the JCBH and PMS can significantly reduce the serum ALP and AST of mice(P<0.01),that JCBH is better than PMSL,but compared to Bifendate Pills and PMS,no significant difference could be found(P>0.05).So JCBH possess significant hepatoprotective activity against CCl 4-induced hepatic damage.

关 键 词：金蚕宝 实验性肝损伤 保护作用 家蚕 护肝作用 四氯化碳 

分 类 号：R285.5[医药卫生—中药学]