动态浊度法定量检测脑组织注射液中细菌内毒素  

Quantitative examination of bacterial endotoxins in the cerebroinjection by kinetic turbidimetric assay

作　　者：宾漫容[1] 马丽[1] 陈焕勇[1] 李虹[1] 张我东 

机构地区：[1]广州军区军事医学研究所,广州510507

出　　处：《中国现代应用药学》2002年第6期493-494,共2页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的 :通过试验以建立脑组织注射液中细菌内毒素定量分析方法。方法 :采用动态浊度法考察脑组织注射液对鲎试剂的干扰作用 ,并与热原检查法进行对比试验分析。结果 :动态浊度法干扰试验结果表明 ,脑组织注射液原液对鲎试验有干扰 ,样品 1∶ 4倍稀释后能有效消除干扰。结论OBJECTIVE:To develop a method for the examination of bacterial endotoxins in cerebroinjection. METHOD:Kinetic turbidimetric assay was used to evaluate the interference of cerebroinjection to TAL, and compared with pyrogen test. RESULTS:Kinetic turbidimetric assay has showed the interference of cerebroinjection to TAL, and the interference could be eliminated when cerebroinjection was four times diluted. CONCLUSION:Kinetic turbidimetric assay can be used in the examination of endotoxins in cerebroinjection.

关 键 词：脑组织注射液 干扰试验 动态浊度法 细菌内毒素 

分 类 号：R927.12[医药卫生—药学]