1991～2001年我院西药品种的比较与分析  

Comparison of drugs in our hospital between 1991 and 2001

作　　者：周权[1] 王欧明[1] 颜小锋[1] 阮邹荣[1] 宋继芬[1] 

机构地区：[1]浙江大学医学院附属二院临床药学室,杭州310009

出　　处：《中国现代应用药学》2002年第6期511-513,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的 :了解新增西药品种的特点 ,指导医院药师业务学习。方法 :对 1991年与 2 0 0 1年我院的西药品种进行比较分析。结果 :有 2 1类西药的品种增幅超过 5 0 %。新增品种中出现了一些药动学特性优良的药物 ,例如 ,不受肝、肾功能影响或合并用药时不易发生代谢性相互作用的药物。普通剂型中出现了一日给药一次的长效药物。纯光学异构体、前体药物、活性代谢产物和结构拼合药也有较大增加。从药效学看 ,新增了治疗机制有突破的 8类新药 ,也出现了对靶位作用更为专属或不良反应较少的药品。复方制剂和新剂型 (缓释剂、控释剂、泡腾片、分散片、咀嚼片、栓剂、凝胶剂、喷雾剂 )得到了大幅度的增加。结论 :医院药师应加强对药物通用名、药物构效关系、药物代谢学、手性药理学、时间药理学、药物治疗学、新剂型。OBJECTIVE:Learn the characteristics of the new drugs in hospital pharmacy and direct the professional education of hospital pharmacists. METHOD:Compare the drugs in our hospital pharmacy between 1991 and 2001. RESULTS:21 classes of drugs inereased 50% than ever. Some drugs have good pharmacokinetic effect, i.e., low risk of metabolic interactions, no need for dose adjustment in patients with hepatic or renal disfunction, etc. Once daily administered conventional preparations, pure optical isomers, prodrugs, active metabolites and structurally conjoined drugs also increased during the period. 8 kinds of new drugs have a break through in pharmacology and therapeutics. Some new drugs have more selective therapeutic effects or have little side effects. A large increase was seen in the number of compound preparations and new dosage forms such as sustained release or controlled release preparation, effervescent tablet, dispersive tablet, chewable tablet, suppository, gel, spray, etc. CONCLUSION:Hospital pharmacists should strengthen learning on generic names, structure activity relationship, drug metabolism, chiral pharmacology, chronopharmacology, therapeutics,new dosage forms, and molecular biology.

关 键 词：新药 品种 医院 药房 

分 类 号：R97[医药卫生—药品]