肝病患者血清HA、PⅢP和Un水平与肝功能、肝脏B超检查结果的关系探讨  

The Relationship between Serum Levels of Hyaluronic Acid, Procollagen Ⅲ Peptide, Undulin and Liver Function, B Ultrasound in Patients with Liver Diseases

作　　者：姚定康[1] 谢渭芬[1] 陈伟中[1] 沈建伟[1] 

机构地区：[1]第二军医大学附属长征医院,上海200003

出　　处：《中西医结合肝病杂志》2002年第6期323-325,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：国家自然科学基金(No:19872074)

摘　　要：目的:探讨肝病患者血清透明质酸(HA)、Ⅱ型前胶原肽(PⅢP)、粗纤维调节素(Un)水平与肝功能、肝脏B超结果的关系,评价其临床应用价值。方法:199例各型肝病,用RIA法检测血清HA、PⅢP,用ELISA法检测血清Un,同时检测肝功能(ALT、TBil、Glb)、肝脏B超,并进行相关分析。结果:慢性肝病各组的HA、PⅢP和Un均高于急性肝炎组(P<0.01,P<0.05),各种慢性肝病组间差异有显著性意义,以活动性肝硬化为最明显。PⅢP、Un与ALT相关(P<0.05),HA与ALT无相关(P>0.05),3者与Glb均相关(P<0.01)。HA、PⅢP和Un与TBil均不相关(P>0.05)。B超异常组的HA、PⅢP和Un水平高于B超正常组(P<0.05,P<0.01)。结论:HA、PⅢP和Un均是诊断肝纤维化的良好指标,但PⅢP、Un与肝炎活动有一定关系,在临床诊断时应与肝功能、B超检查结果综合分析。Objective: To detect the relationship between serum hyaluronic acid (HA), procollagen Ⅲ peptide (PⅢP), Undulin (Un) and the liver function, B ultrasound in patients with liver diseases. Methods: The levels of serum HA and Pin P were detected by RIA in 199 patients with various liver diseases. The serum level of Un were detected by a ELISA method. Results: The results showed that the levels of serum HA, Un and PⅢ P in chronic hepatitis were significantly higher than that in acute hepatitis (P<0.05, P<0.01). Except for HA, both PfⅢP and Un were correlated with serum ALT (P<0.05). All of these three markers were significantly correlated with the serum level of globulin. The levels of them in group with abnormal B ultrasound were higher than those in group with normal B ultrasound (P<0.05, P<0.01). Conclusions: The levels of serum HA, PⅢP and Un were very useful markers to diagnosis liver fibrosis. PⅢP and Un were correlated with chronic hepatitis activity. It should be consider the liver function and B ultrasound as well as serologic fibrotic markers to confirm clinical diagnosis of liver disease.

关 键 词：肝病 透明质酸 Ⅲ型前胶原肽 粗纤维调节素 肝功能 B超 

分 类 号：R575[医药卫生—消化系统]