玉米花粉黄酮类物质对SD大鼠降血脂作用的研究  

Effect of Flavone Material in Maize Pollen on Reducing Blood Fat of SD Rats

作　　者：王开发[1] 王隆华[2] 支崇远[1] 陈素英[2] 邹军[2] 

机构地区：[1]同济大学花粉应用研究中心,200092 [2]华东师大生物系,200062

出　　处：《放射免疫学杂志》2002年第6期368-370,共3页Journal of Radioimmanology

基　　金：上海市自然科学基金资助项目 (98ZA14 0 10 )

摘　　要：目的 :探讨玉米花粉黄酮灶物质对SD大鼠降血脂效应 ,为玉米花粉黄酮类物质做降血脂治疗提供依据。方法 :用高脂高胆固醇饲料复制SD大鼠高脂血症动物模型 ,给予玉米黄酮类物质以观察其治疗高血脂症作用 ,玉米花粉黄酮类物质 ,分别按 4 0 0mg/kg、2 0 0mg/kg、10 0mg/kg体重剂量灌胃给药 ,2 0天后 ,观察给药动物和对照组血清甘油三酯 (TG)和胆固醇 (TG)的变化情况。结果 :给患高血脂症的动物连续 2 0天灌胃玉米黄酮类物质后 ,其血清胆固醇和甘油三酯含量与模型对照组比 ,均有明显差异 ,在三种不同剂量中以中剂量(2 0 0mg/kg)组效果最为显著。结论 :玉米黄酮类物质对实验性高脂血症和高胆固醇血症均有显著的治疗作用。Objective To investigate the effect of flavone material in maize pollen on reducing blood fat in SD rats and to provide the freatment basis. Methods Animal models of SD rats with high blood fat were obtained by feeding high fat and high cholesterol diet. For treatment, flavone materials from maize pollen were given by gavage to three groups of animals at the dose of 400gm/kg, 200mg/kg and 100mg/kg q.d respectively. Changes of the blood contents of triglycoride (TG) and cholesterol were observed 20 days later. Results Animals treated with pollen flavone for 20 days exhibited marked fail in blood TG and cholesterol in all the three groups with best result in the middle dosage group (200mg/kg). Conclusion Flavone materials from maize pollen possessed marked therapeutic effect on experimental hyperlipidemia in rats.

关 键 词：玉米花粉 黄酮类物质 高血脂症 降血脂作用 SD大鼠 

分 类 号：R285.5[医药卫生—中药学]