SYNTHESIS AND DRUG RELEASE OF CROSSLINKING POLYPHOSPHATES  

作　　者：Luo Yi Zhuo Renxi Fan Changlie 

机构地区：[1]Department of Chemistry, Wuhan University, Wuhan 430072

出　　处：《Chinese Journal of Reactive Polymers》1995年第1期127-133,共7页中国反应性高分子（英文版）

摘　　要：A new class of crosslinking polyphosphates were synthesized characterizedby IR 1HNMR, 31PNMR spectroscopy as well as elemental analysis. In vitrodegradation of the polyphosphates obtained and the release of antineoplastic drugMethotrexate (MTX) and contraceptive Levonorgestrel (LNG ) by nsing thesepolymers as matrix were studied. Zero order release rate was rkserved in the case ofLNG release.

关 键 词：Crosslinking polyphosphate METHOTREXATE LEVONORGESTREL Drug release 

分 类 号：R944.9[医药卫生—药剂学] O612.5[医药卫生—药学]