Synthesis of 3, 7-Disubstituted 1, 4-Benzodiazepin-2-one  

作　　者：ShengBiao ZongRuGUO 

机构地区：[1]DepartmentofMedicinalChemistry,InsituteofMateriaMedica,ChineseAcademyofMedicalScience＆PekingUnionMedicalCollege,Beijing100050 [2]DepartmentofMedicinalChemistry,InsituteofMateriaMedica,ChineseAcademyofMed

出　　处：《Chinese Chemical Letters》2002年第5期412-415,共4页中国化学快报（英文版）

摘　　要：A series of 3-methoxycarbonylpropoxy-7-(imidazol-4-ylpropinamide)-1, 3-dihydrogen- 1-methyl-5-phenyl-2H-1, 4-benzodiazepin-2-ones, as farnesyltransferase(Ftase) inhibitors, were synthesized. The preparation of the key intermediate, 7-amino-3-methoxycabonylpropoxy-1- methyl-5-phenyl-2H-1,4-benzodiazepin-2-one, was improved.A series of 3-methoxycarbonylpropoxy-7-(imidazol-4-ylpropinamide)-1, 3-dihydrogen- 1-methyl-5-phenyl-2H-1, 4-benzodiazepin-2-ones, as farnesyltransferase(Ftase) inhibitors, were synthesized. The preparation of the key intermediate, 7-amino-3-methoxycabonylpropoxy-1- methyl-5-phenyl-2H-1,4-benzodiazepin-2-one, was improved.

关 键 词：BENZODIAZEPINE farnesyltransferase. 

分 类 号：O626.5[理学—有机化学]