Organophosphorus Compound DEPBT as a Coupling Reagent for Oligopeptides and Peptoids Synthesis: Studies on Its Mechanism  

作　　者：HuiLIU YunHuaYE 等 

机构地区：[1]DepartmentofMedicinalChemistry,ChinaPharmaceuticalUniversity,Nanjing210009 [2]CollegeofChemistryandMolecularEngineering,PekingUniversity,Beijing100871

出　　处：《Chinese Chemical Letters》2002年第7期601-604,共4页中国化学快报（英文版）

摘　　要：Some oligopeptides and peptoids were synthesized by applying the organophosphorus compound DEPBT as a coupling reagent. D-Biotin-OOBt was obtained unexpectedly. A proposed reaction mechanism for DEPBT-mediated coupling was proved.Some oligopeptides and peptoids were synthesized by applying the organophosphorus compound DEPBT as a coupling reagent. D-Biotin-OOBt was obtained unexpectedly. A proposed reaction mechanism for DEPBT-mediated coupling was proved.

关 键 词：Amino acids PEPTIDES PHOSPHORUS coupling. 

分 类 号：O627.51[理学—有机化学] O629[理学—化学]