(R)-2-羟基-4-苯基丁酸乙酯的合成  

The Synthesis of Ethyl (R)-2-hydroxy-4-phenylbutanoate

作　　者：林文清[1] 张晓梅[1] 宓爱巧[1] 

机构地区：[1]中国科学院成都有机化学研究所不对称合成联合开放实险室

出　　处：《合成化学》2002年第5期385-390,456,共7页Chinese Journal of Synthetic Chemistry

摘　　要：综述了血管紧张素转化酶抑制剂类治疗高血压和充血性心力衰竭药物的关键中间体 ( R) -2 -羟基 -4 -苯基丁酸乙酯的合成方法。参考文献 2Ethyl (R)-2-hydroxy-4-phenylbutanoate is a key intermediate for the syntheses of angiotensin converting enzyme inhibitor(ACEI), which are widely used in clinic as the therapy of hypertesion and congestive heart failure. The synthetic methods of ethyl (R)-2-hydroxy-4-phenylbutanoate were reviewed with 25 references.

关 键 词：(R)-2-羟基-4-苯基丁酸乙酯 药物中间体 合成 综述 血管紧张素转化酶抑制剂 充血性心力衰竭药物 

分 类 号：TQ463.4[化学工程—制药化工] R972[医药卫生—药品]